Xrcc2 X-ray repair cross complementing 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Xrcc2provided by FlyBase
Official Full Name: X-ray repair cross complementing 2provided by FlyBase
Primary source: FLYBASE:FBgn0030931
Locus tag: Dmel_CG6318
See related: AllianceGenome:FB:FBgn0030931
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6318; Dm CG6318; Dmel\CG6318; dmRad51D; Rad51D; XRCC2
Summary: Predicted to enable DNA strand exchange activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA strand invasion and double-strand break repair via homologous recombination. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18500127..18501258)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18394160..18395291)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila Xrcc2 regulates DNA double-strand repair in somatic cells.
Title: Drosophila Xrcc2 regulates DNA double-strand repair in somatic cells.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA strand exchange activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in DNA strand invasion	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in replication fork	IEA Inferred from Electronic Annotation more info

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