U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RunxB Runt related B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33051, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RunxBprovided by FlyBase
    Official Full Name
    Runt related Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259162
    Locus tag
    Dmel_CG42267
    See related
    AllianceGenome:FB:FBgn0259162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15454; CG15455; CG42267; Dmel\CG42267; RUNXB
    Old locus tag
    Dmel_CG15454; Dmel_CG15455
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RunxB in Genome Data Viewer
    Location:
    19D2-19D3; 1-64 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20538497..20567097)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20409524..20438124)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Runt related A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conserved cluster organization of insect Runx genes. Bao R, et al. Dev Genes Evol, 2008 Oct. PMID 18758811
    2. Evolutionary origin and genomic organisation of runt-domain containing genes in arthropods. Duncan EJ, et al. BMC Genomics, 2008 Nov 25. PMID 19032778, Free PMC Article
    3. The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms. Rennert J, et al. BMC Evol Biol, 2003 Mar 24. PMID 12659662, Free PMC Article
    4. Fine scale structural variants distinguish the genomes of Drosophila melanogaster and D. pseudoobscura. Macdonald SJ, et al. Genome Biol, 2006. PMID 16872532, Free PMC Article
    5. Interactions and Feedbacks in E-Cadherin Transcriptional Regulation. Ramirez Moreno M, et al. Front Cell Dev Biol, 2021. PMID 34262912, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    runt related B
    Names
    CG42267-PC
    RunxB-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20538497..20567097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272816.2 → NP_001259745.1  runt related B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRA9
      Conserved Domains (1) summary
      pfam00853
      Location:118 → 239
      Runt; Runt domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRA9 Q9VRA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous