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    bark bark beetle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    barkprovided by FlyBase
    Official Full Name
    bark beetleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031571
    Locus tag
    Dmel_CG3921
    See related
    AllianceGenome:FB:FBgn0031571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aka; Aka; Bark; CG3921; Dmel\CG3921
    Summary
    Predicted to enable carbohydrate binding activity. Involved in cell-cell junction organization and open tracheal system development. Located in lateral plasma membrane; septate junction; and tricellular tight junction. Is expressed in several structures, including adult head; embryonic head epidermis; embryonic salivary gland duct; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bark in Genome Data Viewer
    Location:
    24C4-24C5; 2-11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3787167..3802726)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3787167..3802726)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Regulator of eph expression Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Palmitoylation of proteolipid protein M6 promotes tricellular junction assembly in epithelia of Drosophila. Schleutker R, et al. J Cell Sci, 2024 Mar 15. PMID 38345097
    2. Scribble and Discs Large mediate tricellular junction formation. Sharifkhodaei Z, et al. Development, 2019 Sep 23. PMID 31444218
    3. Coordination of Septate Junctions Assembly and Completion of Cytokinesis in Proliferative Epithelial Tissues. Daniel E, et al. Curr Biol, 2018 May 7. PMID 29706514
    4. The claudin Megatrachea protein complex. Jaspers MH, et al. J Biol Chem, 2012 Oct 26. PMID 22930751, Free PMC Article
    5. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila. Wittek A, et al. Curr Biol, 2020 Nov 2. PMID 32857972

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
      Title: The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
    2. Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
      Title: Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
    3. Disentanglement of the neighbour cells from the midbody, and the midbody movement, are impaired in the absence of the Gliotactin (Gli) and Anakonda (Aka) TCJ proteins.
      Title: Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis.
    4. Study describes the identification and functional characterisation of the putative scavenger receptor-like protein Bark beetle (Bark; CG3921) Bark is required for septate junction (SJ) maturation in developing epithelial cells, in addition Bark controls epithelial cell adhesion within the SJ compartment.
      Title: Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell junction maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube length, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    involved_in tricellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septate junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in tricellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bark beetle
    Names
    CG3921-PA
    CG3921-PB
    CG3921-PC
    anakonda
    bark-PA
    bark-PB
    bark-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3787167..3802726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258935.3 → NP_001245864.1  bark beetle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245864.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NDE3, Q9VQV1
      Conserved Domains (5) summary
      smart00034
      Location:2604 → 2699
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00202
      Location:1071 → 1175
      SR; Scavenger receptor Cys-rich
      cd00041
      Location:459 → 552
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00530
      Location:1076 → 1174
      SRCR; Scavenger receptor cysteine-rich domain
      pfam13229
      Location:579 → 752
      Beta_helix; Right handed beta helix region

    2. NM_134964.4 → NP_608808.1  bark beetle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NDE3
      Related
      FBpp0077185
      Conserved Domains (5) summary
      smart00034
      Location:2596 → 2691
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00202
      Location:1071 → 1175
      SR; Scavenger receptor Cys-rich
      cd00041
      Location:459 → 552
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00530
      Location:1076 → 1174
      SRCR; Scavenger receptor cysteine-rich domain
      pfam13229
      Location:579 → 752
      Beta_helix; Right handed beta helix region

    3. NM_001258936.2 → NP_001245865.1  bark beetle, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NDE3, Q9VQV1
      Conserved Domains (5) summary
      smart00034
      Location:2604 → 2699
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00202
      Location:1071 → 1175
      SR; Scavenger receptor Cys-rich
      cd00041
      Location:459 → 552
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00530
      Location:1076 → 1174
      SRCR; Scavenger receptor cysteine-rich domain
      pfam13229
      Location:579 → 752
      Beta_helix; Right handed beta helix region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDE3.1 M9NDE3

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