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    Cap-D3 Chromosome associated protein D3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cap-D3provided by FlyBase
    Official Full Name
    Chromosome associated protein D3provided by FlyBase
    Primary source
    FLYBASE:FBgn0051989
    Locus tag
    Dmel_CG31989
    See related
    AllianceGenome:FB:FBgn0051989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE74832; CAP-D2; cap-D3; CAP-D3; CapD3; CG14019; CG31989; CG6922; dCap-D3; dCAP-D3; Dmel\CG31989
    Summary
    Enables chromatin binding activity. Involved in several processes, including chromosome separation; male meiosis chromosome segregation; and regulation of DNA metabolic process. Located in nucleus. Colocalizes with chromosome, centromeric region. Is expressed in organism. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD3 (non-SMC condensin II complex subunit D3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cap-D3 in Genome Data Viewer
    Location:
    25E5-25E5; 2-17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5525905..5535958)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5525905..5535958)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene clot Neighboring gene Vacuolar protein sorting 52 Neighboring gene antisense RNA:CR44793 Neighboring gene Elongator complex protein 4 Neighboring gene Cytochrome c oxidase copper chaperone COX11 Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q6 Neighboring gene tombola Neighboring gene uncharacterized protein Neighboring gene Helicase at 25E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. Deutschman E, et al. J Cell Sci, 2019 Nov 20. PMID 31653782, Free PMC Article
    2. Comparing and Contrasting the Effects of Drosophila Condensin II Subunit dCAP-D3 Overexpression and Depletion in Vivo. Deutschman E, et al. Genetics, 2018 Oct. PMID 30068527, Free PMC Article
    3. Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes. Bauer CR, et al. PLoS Genet, 2012. PMID 22956908, Free PMC Article
    4. Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2. Wallace HA, et al. G3 (Bethesda), 2015 Mar 9. PMID 25758823, Free PMC Article
    5. Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster. Crawford BI, et al. Nat Commun, 2024 Mar 28. PMID 38548759, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Altering dCAP-D3 levels in either direction has detrimental effects on mitotic timing, the regulation of gene expression, and organism development.
      Title: Comparing and Contrasting the Effects of Drosophila Condensin II Subunit dCAP-D3 Overexpression and Depletion in Vivo.
    2. These findings identify a novel role for the anti-pairing activities of dCAP-D3/Condensin II and uncover a new way in which dCAP-D3/Condensin II influences local chromatin structure to help maintain genome stability
      Title: Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells.
    3. These results describe a novel, non-mitotic role for the RBF1 and dCAP-D3 proteins in activation of the Drosophila immune system and suggest dCAP-D3 has an important role at specific subsets of RBF1-dependent genes.
      Title: A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity.
    4. dCap-D3 mutants exhibit chromatin condensation defects, and mutant alleles of dCap-D3
      Title: RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of condensin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromosome associated protein D3
    Names
    CG31989-PA
    CG31989-PB
    Cap-D3-PA
    Cap-D3-PB
    Chromosome-associated protein D3
    dCAP-D3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5525905..5535958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135091.4 → NP_608935.2  chromosome associated protein D3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608935.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGJ9, Q9VMQ4
      Related
      FBpp0078730
      Conserved Domains (1) summary
      pfam12717
      Location:889 → 999
      Cnd1; non-SMC mitotic condensation complex subunit 1

    2. NM_001169416.2 → NP_001162887.1  chromosome associated protein D3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGJ9, Q9VMQ4
      Conserved Domains (1) summary
      pfam12717
      Location:889 → 999
      Cnd1; non-SMC mitotic condensation complex subunit 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGJ9 Q8IGJ9
    Q8MSN8 Q8MSN8
    Q8SY09 Q8SY09
    Q9VMQ4 Q9VMQ4

    Gene LinkOut

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