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    CG9098 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9098provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031762
    Locus tag
    Dmel_CG9098
    See related
    AllianceGenome:FB:FBgn0031762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9098
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Ras protein signal transduction. Is expressed in embryonic brain; larval nervous system; and larval ventral nerve cord. Orthologous to several human genes including BCAR3 (BCAR3 adaptor protein, NSP family member) and SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9098 in Genome Data Viewer
    Location:
    26B2-26B2; 2-18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6007364..6012338, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6007364..6012338, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Tetraspanin 26A Neighboring gene antisense RNA:CR43866 Neighboring gene beta galactosidase Neighboring gene Homeodomain protein 2.0 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whole-genome expression profiles identify gene batteries in Drosophila. Stathopoulos A, et al. Dev Cell, 2002 Oct. PMID 12408796
    2. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. van Dam TJ, et al. Cell Signal, 2009 Nov. PMID 19567266
    3. PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance. Parisi E, et al. Int J Mol Sci, 2023 Jun 30. PMID 37446068, Free PMC Article
    4. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article
    5. Alcohol Causes Lasting Differential Transcription in Drosophila Mushroom Body Neurons. Petruccelli E, et al. Genetics, 2020 May. PMID 32132098, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISM
    Inferred from Sequence Model
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Ras protein signal transduction ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9098-PA
    CG9098-PB
    CG9098-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6007364..6012338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273192.1 → NP_001260121.1  uncharacterized protein Dmel_CG9098, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T010
      Conserved Domains (2) summary
      cd10337
      Location:42 → 176
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:469 → 606
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. NM_135135.3 → NP_608979.2  uncharacterized protein Dmel_CG9098, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608979.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9B3, Q9VMJ4
      Related
      FBpp0078859
      Conserved Domains (4) summary
      smart00454
      Location:47 → 103
      SAM; Sterile alpha motif
      cd10337
      Location:233 → 367
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      pfam00536
      Location:43 → 102
      SAM_1; SAM domain (Sterile alpha motif)
      cl02485
      Location:660 → 797
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    3. NM_164672.3 → NP_723142.1  uncharacterized protein Dmel_CG9098, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T010
      Related
      FBpp0078860
      Conserved Domains (2) summary
      cd10337
      Location:42 → 176
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:469 → 606
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T010 Q8T010
    Q8T9B3 Q8T9B3
    Q9VMJ4 Q9VMJ4

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