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    SLC5A11 Sodium/solute co-transporter-like 5A11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34117, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLC5A11provided by FlyBase
    Official Full Name
    Sodium/solute co-transporter-like 5A11provided by FlyBase
    Primary source
    FLYBASE:FBgn0031998
    Locus tag
    Dmel_CG8451
    See related
    AllianceGenome:FB:FBgn0031998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8451; CG8451-PA; Dmel\CG8451
    Summary
    Predicted to enable symporter activity. Involved in adult feeding behavior and behavioral response to nutrient. Predicted to be located in membrane. Is expressed in several structures, including adult anterior midgut epithelium; adult brain; adult gnathal ganglion; ellipsoid body; and organism subdivision. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SLC5A11 in Genome Data Viewer
    Location:
    28F1-28F1; 2-30 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8200465..8205132, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8200465..8205132, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44116 Neighboring gene uncharacterized protein Neighboring gene Post-GPI attachment to proteins 5 Neighboring gene antisense RNA:CR44119 Neighboring gene long non-coding RNA:CR44120 Neighboring gene long non-coding RNA:CR44121

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immediate and delayed effects of nutrient-sensing in fruit fly Drosophila melanogaster. Kahraman A, et al. Behav Processes, 2019 Jul. PMID 31051219
    2. A quantitative feeding assay in adult Drosophila reveals rapid modulation of food ingestion by its nutritional value. Qi W, et al. Mol Brain, 2015 Dec 21. PMID 26692189, Free PMC Article
    3. Drosophila SLC5A11 Mediates Hunger by Regulating K(+) Channel Activity. Park JY, et al. Curr Biol, 2016 Aug 8. PMID 27397890, Free PMC Article
    4. Sex-specific pharmacokinetic response to phytoestrogens in Drosophila melanogaster. Sadova N, et al. Biomed Pharmacother, 2024 Jun. PMID 38663102
    5. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to nutrient IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/solute co-transporter-like 5A11
    Names
    CG8451-PA
    NA-dependent multivitamin transporter
    SLC5A11-PA
    cupcake

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8200465..8205132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135348.3 → NP_609192.1  Sodium/solute co-transporter-like 5A11 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TZ3, Q9VLR8
      Related
      FBpp0079253
      Conserved Domains (1) summary
      cd11492
      Location:17 → 556
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLR8 Q9VLR8

    Gene LinkOut

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