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    CG31729 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31729provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051729
    Locus tag
    Dmel_CG31729
    See related
    AllianceGenome:FB:FBgn0051729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16823; CG6263; DmCG31729; Dmel\CG31729; P4-ATPase
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Is expressed in adult head. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth and behavioral abnormalities. Orthologous to several human genes including ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See CG31729 in Genome Data Viewer
    Location:
    34B4-34B5; 2-48 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13289997..13301668)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13289997..13301668)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44083 Neighboring gene antisense RNA:CR44972 Neighboring gene DNA fragmentation factor-related protein 4 Neighboring gene UV-resistance associated gene Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene headbutt Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functions of phospholipid flippases. Tanaka K, et al. J Biochem, 2011 Feb. PMID 21134888
    2. Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis. Yoshida M, et al. Sci Rep, 2016 Jul 29. PMID 27469628, Free PMC Article
    3. Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion. Gradilla AC, et al. Nat Commun, 2014 Dec 4. PMID 25472772
    4. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250
    5. P-type ATPases in Caenorhabditis and Drosophila: implications for evolution of the P-type ATPase subunit families with special reference to the Na,K-ATPase and H,K-ATPase subgroup. Okamura H, et al. J Membr Biol, 2003 Jan 1. PMID 12532273

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31729-PA
    CG31729-PB
    CG31729-PC
    CG31729-PD
    NP_001285886.1
    NP_001285887.1
    NP_609634.1
    NP_723806.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13289997..13301668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135790.4 → NP_609634.1  uncharacterized protein Dmel_CG31729, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T082, Q9VK06
      Related
      FBpp0080040
      Conserved Domains (6) summary
      TIGR01652
      Location:228 → 1252
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:323 → 525
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:704 → 783
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:227 → 279
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1021 → 1249
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:975 → 1019
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001298958.1 → NP_001285887.1  uncharacterized protein Dmel_CG31729, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5C6, X2J9M9
      Conserved Domains (5) summary
      TIGR01652
      Location:2 → 990
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:61 → 263
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:442 → 521
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:759 → 987
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:713 → 757
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. NM_001298957.1 → NP_001285886.1  uncharacterized protein Dmel_CG31729, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5C6, X2JDZ6
      Conserved Domains (6) summary
      TIGR01652
      Location:48 → 1072
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:143 → 345
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:524 → 603
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:47 → 99
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:841 → 1069
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:795 → 839
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. NM_165038.3 → NP_723806.1  uncharacterized protein Dmel_CG31729, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5C6, Q9VK04
      Related
      FBpp0080041
      Conserved Domains (6) summary
      TIGR01652
      Location:59 → 1083
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:154 → 356
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:535 → 614
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:58 → 110
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:852 → 1080
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:806 → 850
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK04 Q9VK04
    Q9VK06 Q9VK06
    X2J9M9 X2J9M9
    X2JDZ6 X2JDZ6

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