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    Hsp60D Heat shock protein 60D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsp60Dprovided by FlyBase
    Official Full Name
    Heat shock protein 60Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032525
    Locus tag
    Dmel_CG16954
    See related
    AllianceGenome:FB:FBgn0032525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16954; Dmel\CG16954; HSP60D
    Summary
    Predicted to enable ATP hydrolysis activity and protein-folding chaperone binding activity. Involved in apoptotic process. Predicted to be active in mitochondrial inner membrane and mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hsp60D in Genome Data Viewer
    Location:
    34C1-34C1; 2-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13447538..13449497, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13447538..13449497, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45683 Neighboring gene tehao Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene long non-coding RNA:CR45684 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Delayed discovery of Hsp60 and subsequent characterization of moonlighting functions of multiple Hsp60 genes in Drosophila: a personal historical perspective. Lakhotia SC. J Genet, 2022. PMID 36330787
    2. Heat shock genes - integrating cell survival and death. Arya R, et al. J Biosci, 2007 Apr. PMID 17536179
    3. Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response. Morrow G, et al. Biogerontology, 2016 Feb. PMID 26155908
    4. Elevation of major constitutive heat shock proteins is heat shock factor independent and essential for establishment and growth of Lgl loss and Yorkie gain-mediated tumors in Drosophila. Singh G, et al. Cell Stress Chaperones, 2022 Jul. PMID 35704239, Free PMC Article
    5. The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility. Sarkar S, et al. J Genet, 2005 Dec. PMID 16385159

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The downregulation of Hsp60D protein blocks caspase-dependent induced apoptosis.
      Title: Hsp60D is essential for caspase-mediated induced apoptosis in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic mitochondrial changes IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 60D
    Names
    CG16954-PA
    CG16954-PB
    Hsp60D-PA
    Hsp60D-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13447538..13449497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135812.2 → NP_609656.1  heat shock protein 60D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJX7
      Related
      FBpp0080095, FBtr0080517
      Conserved Domains (2) summary
      PTZ00114
      Location:13 → 546
      PTZ00114; Heat shock protein 60; Provisional
      cd03344
      Location:18 → 536
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...

    2. NM_165043.2 → NP_723818.1  heat shock protein 60D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJX7
      Related
      FBpp0080096
      Conserved Domains (2) summary
      PTZ00114
      Location:13 → 546
      PTZ00114; Heat shock protein 60; Provisional
      cd03344
      Location:18 → 536
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJX7 Q9VJX7

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