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    grnd grindelwald [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35103, updated on 17-Dec-2024

    Summary

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    Official Symbol
    grndprovided by FlyBase
    Official Full Name
    grindelwaldprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032682
    Locus tag
    Dmel_CG10176
    See related
    AllianceGenome:FB:FBgn0032682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10176; Dmel\CG10176; Grnd
    Summary
    Enables tumor necrosis factor receptor activity. Involved in positive regulation of JNK cascade and tumor necrosis factor-mediated signaling pathway. Is active in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; clypeo-labral anlage; clypeo-labral primordium; dorsal ectoderm; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See grnd in Genome Data Viewer
    Location:
    36F5-36F5; 2-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18485417..18488021)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18485417..18488021)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene let-7 Complex Neighboring gene mir-125 stem loop Neighboring gene uncharacterized protein Neighboring gene kon-tiki Neighboring gene UDP-glycosyltransferase family 301 member D1 Neighboring gene long non-coding RNA:CR44903 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling. Kodra AL, et al. Genetics, 2024 Sep 4. PMID 38985651, Free PMC Article
    2. Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration. Esteban-Collado J, et al. EMBO J, 2024 Sep. PMID 39020149, Free PMC Article
    3. Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis. Chang YC, et al. Sci Rep, 2020 Jul 15. PMID 32669615, Free PMC Article
    4. A novel injury paradigm in the central nervous system of adult Drosophila: molecular, cellular and functional aspects. Losada-Pérez M, et al. Dis Model Mech, 2021 May 1. PMID 34061177, Free PMC Article
    5. Gene Set Enrichment Analysis and Genetic Experiment Reveal Changes in Cell Signaling Pathways Induced by α-Synuclein Overexpression. Huang Y, et al. Biomedicines, 2023 Jan 18. PMID 36830800, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
      Title: Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tumor necrosis factor receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of negative regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    grindelwald
    Names
    CG10176-PB
    CG10176-PC
    grnd-PB
    grnd-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18485417..18488021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273609.1 → NP_001260538.1  grindelwald, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXT4, Q9VJ83

    2. NM_136036.4 → NP_609880.2  grindelwald, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609880.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXT4, Q9VJ83
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ83.2 Q9VJ83

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