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    amd alpha methyl dopa-resistant [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    amdprovided by FlyBase
    Official Full Name
    alpha methyl dopa-resistantprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000075
    Locus tag
    Dmel_CG10501
    See related
    AllianceGenome:FB:FBgn0000075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AMD-r; CG10501; CG17345; Dmel\CG10501; fAMD; l(2)37Bk; l(2)amd; l(2)amd alpha-methyldopa hypersensitive; l(2)amd[H]; X04695
    Summary
    Enables 3,4-dihydroxyphenylacetaldehyde synthase activity. Involved in catecholamine metabolic process and chitin-based cuticle development. Predicted to be active in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; ganglia; gut section; imaginal disc; and larval tracheal system. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See amd in Genome Data Viewer
    Location:
    37C1-37C1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19110154..19114110)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19110154..19114110)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lim3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44905 Neighboring gene uncharacterized protein Neighboring gene Dopa decarboxylase Neighboring gene Prohibitin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects. Vavricka C, et al. PLoS One, 2011 Jan 24. PMID 21283636, Free PMC Article
    2. Vitelline membrane biogenesis in Drosophila requires the activity of the alpha-methyl dopa hypersensitive gene (I(2)amd) in both the germline and follicle cells. Konrad KD, et al. Insect Mol Biol, 1993. PMID 8269096
    3. The selection for mutants in Drosophila melanogaster hypersensitive to alpha-methyl dopa, a dopa decarboxylase inhibitor. Sparrow JC, et al. Mol Gen Genet, 1974 May 21. PMID 4209419
    4. BuT2 is a member of the third major group of hAT transposons and is involved in horizontal transfer events in the genus Drosophila. Rossato DO, et al. Genome Biol Evol, 2014 Feb. PMID 24459285, Free PMC Article
    5. Biochemical identification of residues that discriminate between 3,4-dihydroxyphenylalanine decarboxylase and 3,4-dihydroxyphenylacetaldehyde synthase-mediated reactions. Liang J, et al. Insect Biochem Mol Biol, 2017 Dec. PMID 29037755

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3,4-dihydroxyphenylacetaldehyde synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aromatic-L-amino-acid decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in catecholamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in catecholamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha methyl dopa-resistant
    Names
    3,4-dihydroxyphenylacetaldehyde synthase
    CG10501-PA
    CG10501-PB
    DHPA synthase
    DHPAA synthase
    alpha methyl dopa
    alpha-methotrexate deficient
    alpha-methyl dopa resistant
    amd-PA
    amd-PB
    dopa decarboxylase
    transcription unit No. 1
    NP_476592.1
    NP_724162.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19110154..19114110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165278.2 → NP_724162.1  alpha methyl dopa-resistant, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BID9
      Related
      FBpp0080697
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    2. NM_057244.4 → NP_476592.1  alpha methyl dopa-resistant, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18486, Q9VIZ8, Q9VIZ9
      UniProtKB/TrEMBL
      C9QP35, H5V873
      Related
      FBpp0080698
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18486.2 P18486
    Q5BID9 Q5BID9

    Gene LinkOut

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    Chemical Information
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