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    Pyroxd1 Pyridine nucleotide-disulfide oxidoreductase domain 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35296, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pyroxd1provided by FlyBase
    Official Full Name
    Pyridine nucleotide-disulfide oxidoreductase domain 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032846
    Locus tag
    Dmel_CG10721
    See related
    AllianceGenome:FB:FBgn0032846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38B.14; CG10721; Dmel\CG10721
    Summary
    Predicted to enable oxidoreductase activity. Human ortholog(s) of this gene implicated in myofibrillar myopathy 8. Orthologous to human PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pyroxd1 in Genome Data Viewer
    Location:
    38B5-38B6; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20091435..20093152)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20091435..20093152)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nebbish Neighboring gene fledgling of Klp38B Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 13 Neighboring gene nessun dorma Neighboring gene mitochondrial ribosomal protein S18B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan. Saha M, et al. Physiol Genomics, 2018 Nov 1. PMID 30345904, Free PMC Article
    2. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article
    3. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pyridine nucleotide-disulfide oxidoreductase domain 1
    Names
    CG10721-PA
    CG10721-PB
    Pyroxd1-PA
    Pyroxd1-PB
    NP_001260619.1
    NP_610023.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20091435..20093152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273690.1 → NP_001260619.1  pyridine nucleotide-disulfide oxidoreductase domain 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIP2
      Conserved Domains (1) summary
      pfam07992
      Location:8 → 355
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_136179.3 → NP_610023.1  pyridine nucleotide-disulfide oxidoreductase domain 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIP2
      Related
      FBpp0080865
      Conserved Domains (1) summary
      pfam07992
      Location:8 → 355
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIP2.1 Q9VIP2

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