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    Pngl PNGase-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pnglprovided by FlyBase
    Official Full Name
    PNGase-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033050
    Locus tag
    Dmel_CG7865
    See related
    AllianceGenome:FB:FBgn0033050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7865; Dmel\CG7865; dNGLY1; ngly1; NGLY1; png1; Png1; PNGase; pngl
    Summary
    Enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Involved in positive regulation of BMP signaling pathway and visceral mesoderm-endoderm interaction involved in midgut development. Located in cytosol. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; gonad; imaginal disc; and larval central nervous system. Used to study congenital disorder of deglycosylation 1. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 1. Orthologous to human NGLY1 (N-glycanase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pngl in Genome Data Viewer
    Location:
    42A7-42A8; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6017739..6020695)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1905244..1908200)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Src oncogene at 42A Neighboring gene Actin 42A Neighboring gene Ser/Thr-rich caspase Neighboring gene SREBP cleavage activating protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Drosophila Model of NGLY1 Deficiency. Rodriguez TP, et al. G3 (Bethesda), 2018 Jul 2. PMID 29735526, Free PMC Article
    2. Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Owings KG, et al. Hum Mol Genet, 2018 Mar 15. PMID 29346549, Free PMC Article
    3. An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency. Hope KA, et al. PLoS Genet, 2022 Jun. PMID 35653343, Free PMC Article
    4. Evidence for an essential deglycosylation-independent activity of PNGase in Drosophila melanogaster. Funakoshi Y, et al. PLoS One, 2010 May 10. PMID 20479940, Free PMC Article
    5. Tracing the NGLY1 footprints: insights from Drosophila. Pandey A, et al. J Biochem, 2022 Feb 21. PMID 34270726, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoprotein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visceral mesoderm-endoderm interaction involved in midgut development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PNGase-like
    Names
    CG7865-PA
    CG7865-PC
    PNGase
    Pngl-PA
    Pngl-PC
    NP_610192.1
    NP_724444.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6017739..6020695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165454.3 → NP_724444.3  PNGase-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724444.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KRR5, Q8IGW3, Q8MRV8, Q9NBD5, Q9V9J5
      Conserved Domains (6) summary
      COG1305
      Location:282 → 378
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam01841
      Location:278 → 341
      Transglut_core; Transglutaminase-like superfamily
      pfam03835
      Location:325 → 383
      Rad4; Rad4 transglutaminase-like domain
      pfam04721
      Location:444 → 630
      PAW; PNGase C-terminal domain, mannose-binding module PAW
      pfam09409
      Location:30 → 107
      PUB; PUB domain
      cl01498
      Location:98 → 185
      CitX; Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

    2. NM_136348.3 → NP_610192.1  PNGase-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KRR5, Q8IGW3, Q8MRV8, Q9NBD5, Q9V9J5
      Related
      FBpp0085325
      Conserved Domains (6) summary
      COG1305
      Location:282 → 378
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam01841
      Location:278 → 341
      Transglut_core; Transglutaminase-like superfamily
      pfam03835
      Location:325 → 383
      Rad4; Rad4 transglutaminase-like domain
      pfam04721
      Location:444 → 630
      PAW; PNGase C-terminal domain, mannose-binding module PAW
      pfam09409
      Location:30 → 107
      PUB; PUB domain
      cl01498
      Location:98 → 185
      CitX; Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KRR5.1 Q7KRR5

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