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    CNT1 Concentrative nucleoside transporter 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CNT1provided by FlyBase
    Official Full Name
    Concentrative nucleoside transporter 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033371
    Locus tag
    Dmel_CG11778
    See related
    AllianceGenome:FB:FBgn0033371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11778; cnt1; DmCnt1; Dmel\CG11778
    Summary
    Predicted to enable nucleoside:sodium symporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; late elongation-stage spermatid; mid-late elongation-stage spermatid; and testis. Orthologous to human SLC28A1 (solute carrier family 28 member 1); SLC28A2 (solute carrier family 28 member 2); and SLC28A3 (solute carrier family 28 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CNT1 in Genome Data Viewer
    Location:
    45A1-45A1; 2-60 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9082395..9085717)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4969900..4973222)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene anachronism Neighboring gene antisense RNA:CR45924 Neighboring gene Concentrative nucleoside transporter 2 Neighboring gene uncharacterized protein Neighboring gene DEAD box protein 45A Neighboring gene NAD kinase 2, mitochondrial Neighboring gene Bootlegger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation in Drosophila concentrative nucleoside transporter 1 alters spermatid maturation and mating behavior. Maaroufi HO, et al. Front Cell Dev Biol, 2022. PMID 36105362, Free PMC Article
    2. Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter. Machado J, et al. Physiol Genomics, 2007 Feb 12. PMID 17090699
    3. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. Knight D, et al. J Neurosci, 2010 Apr 7. PMID 20371825, Free PMC Article
    4. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article
    5. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    concentrative nucleoside transporter 1
    Names
    CG11778-PB
    CNT1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9082395..9085717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136603.3 → NP_610447.2  concentrative nucleoside transporter 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610447.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7N3, B3DN99
      Conserved Domains (4) summary
      TIGR00804
      Location:184 → 581
      nupC; nucleoside transporter
      pfam01773
      Location:188 → 257
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:372 → 581
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:271 → 366
      Gate; Nucleoside recognition
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7N3 A1Z7N3

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