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    CG13893 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13893provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035146
    Locus tag
    Dmel_CG13893
    See related
    AllianceGenome:FB:FBgn0035146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13893
    Summary
    Predicted to enable phosphatidylcholine transporter activity and phosphatidylinositol transfer activity. Predicted to be involved in phospholipid transport. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic head sensory system; embryonic/larval posterior spiracle; ganglia; and larval nervous system. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2); SEC14L3 (SEC14 like lipid binding 3); and SEC14L4 (SEC14 like lipid binding 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13893 in Genome Data Viewer
    Location:
    61C6-61C6; 3-0.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (599094..604008, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (599094..604008, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ppm1 Neighboring gene Kahuli Neighboring gene Mediator complex subunit 14 Neighboring gene antisense RNA:CR45807 Neighboring gene Rhythmically expressed gene 2 Neighboring gene long non-coding RNA:CR44513

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The bantam gene regulates Drosophila growth. Hipfner DR, et al. Genetics, 2002 Aug. PMID 12196398, Free PMC Article
    2. Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells. Pang LY, et al. Elife, 2023 Oct 13. PMID 37831064, Free PMC Article
    3. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article
    4. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article
    5. The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster. Jehrke L, et al. Sci Rep, 2018 Apr 18. PMID 29670218, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylcholine transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13893-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      599094..604008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138198.4 → NP_612042.3  uncharacterized protein Dmel_CG13893 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612042.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYC4, Q9W0P7
      Related
      FBpp0072461
      Conserved Domains (3) summary
      smart01100
      Location:16 → 57
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:75 → 246
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam13897
      Location:303 → 381
      GOLD_2; Golgi-dynamics membrane-trafficking
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYC4 Q8SYC4

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