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    Tsp66E Tetraspanin 66E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp66Eprovided by FlyBase
    Official Full Name
    Tetraspanin 66Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035936
    Locus tag
    Dmel_CG4999
    See related
    AllianceGenome:FB:FBgn0035936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4999; Dm.Tsp66E; Dmel\CG4999; tsp66E
    Summary
    Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; egg chamber; embryonic anal pad; and gut section. Orthologous to human CD37 (CD37 molecule) and CD82 (CD82 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp66E in Genome Data Viewer
    Location:
    66E3-66E4; 3-27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8912499..8932065)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8905599..8925165)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45871 Neighboring gene transfer RNA:Threonine-AGT 3-1 pseudogene Neighboring gene Minichromosome maintenance 7 Neighboring gene Transient receptor potential cation channel A1 Neighboring gene long non-coding RNA:CR43970 Neighboring gene misfire Neighboring gene uncharacterized protein Neighboring gene orb2 Neighboring gene Gram-negative bacteria binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization. Han SY, et al. FEBS Lett, 2012 Nov 16. PMID 23068610
    2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    3. Integrating GWAS and Transcriptomics to Identify the Molecular Underpinnings of Thermal Stress Responses in Drosophila melanogaster. Lecheta MC, et al. Front Genet, 2020. PMID 32655626, Free PMC Article
    4. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article
    5. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Tsp66E and Tsp74F mutant ovaries had elevated inflated gene product alphaPS2 integrin levels and reduced endocytic trafficking.
      Title: Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin 66E
    Names
    CG4999-PA
    CG4999-PB
    CG4999-PC
    Tsp66E-PA
    Tsp66E-PB
    Tsp66E-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8912499..8932065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168298.1 → NP_729423.1  tetraspanin 66E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3E5
      Related
      FBpp0076233, FBtr0076506
      Conserved Domains (2) summary
      cd03156
      Location:116 → 231
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:9 → 258
      Tetraspannin; Tetraspanin family

    2. NM_168299.2 → NP_729424.1  tetraspanin 66E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3E5
      Related
      FBpp0076235
      Conserved Domains (2) summary
      cd03156
      Location:116 → 231
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:9 → 258
      Tetraspannin; Tetraspanin family

    3. NM_079261.5 → NP_523985.1  tetraspanin 66E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3E5
      Related
      FBpp0076234
      Conserved Domains (2) summary
      cd03156
      Location:116 → 231
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:9 → 258
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3E5 Q9V3E5

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