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    twy twitchy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    twyprovided by FlyBase
    Official Full Name
    twitchyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036206
    Locus tag
    Dmel_CG5964
    See related
    AllianceGenome:FB:FBgn0036206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5964; Dmel\CG5964; fbf1; Fbf1; FBF1
    Summary
    Involved in cytosolic ciliogenesis and non-motile cilium assembly. Part of ciliary transition fiber. Is expressed in Johnston organ; antennal segment 3 sense organ; scolopidial cilium; spermatid; and spermatocyte. Orthologous to human FBF1 (Fas binding factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See twy in Genome Data Viewer
    Location:
    68D6-68D6; 3-36 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11790212..11793283, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11783312..11786383, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 3-kinase 68D Neighboring gene Tim13 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 68D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility. Hodge SH, et al. Biol Open, 2021 Aug 15. PMID 34357392, Free PMC Article
    2. Drosophila transition fibers are essential for IFT-dependent ciliary elongation but not basal body docking and ciliary budding. Hou Y, et al. Curr Biol, 2023 Feb 27. PMID 36669498
    3. IFT52 plays an essential role in sensory cilia formation and neuronal sensory function in Drosophila. Hou YN, et al. Insect Sci, 2023 Aug. PMID 36326027
    4. Functional Analysis of Hydrolethalus Syndrome Protein HYLS1 in Ciliogenesis and Spermatogenesis in Drosophila. Hou Y, et al. Front Cell Dev Biol, 2020. PMID 32509774, Free PMC Article
    5. CEP290 is essential for the initiation of ciliary transition zone assembly. Wu Z, et al. PLoS Biol, 2020 Dec. PMID 33370260, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytosolic ciliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of epithelial cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ciliary transition fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ciliary transition fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    twitchy
    Names
    CG5964-PA
    twy-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11790212..11793283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140250.1 → NP_648507.1  twitchy [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR73, Q9VTN6
      Related
      FBpp0075816, FBtr0076085
      Conserved Domains (3) summary
      COG1196
      Location:410 → 743
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK14971
      Location:139 → 320
      PRK14971; DNA polymerase III subunits gamma and tau; Provisional
      TIGR02168
      Location:610 → 882
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR73 Q8MR73
    Q9VTN6 Q9VTN6

    Gene LinkOut

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