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    RpL35A Ribosomal protein L35A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40654, updated on 17-Dec-2024

    Summary

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    Official Symbol
    RpL35Aprovided by FlyBase
    Official Full Name
    Ribosomal protein L35Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037328
    Locus tag
    Dmel_CG2099
    See related
    AllianceGenome:FB:FBgn0037328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey39; CG2099; Dmel\CG2099; L33e; L35a; Rp L35A; Rpl35A
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit biogenesis. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpL35A in Genome Data Viewer
    Location:
    83A4-83A4; 3-47.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5465630..5467101, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1291352..1292823, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pancreatic eIF-2alpha kinase Neighboring gene Polymerase (DNA-directed), delta interacting protein 2 Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene Snf5-related 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Population suppression with dominant female-lethal alleles is boosted by homing gene drive. Zhu J, et al. BMC Biol, 2024 Sep 11. PMID 39256812, Free PMC Article
    2. A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population. Champer J, et al. Proc Natl Acad Sci U S A, 2020 Sep 29. PMID 32929034, Free PMC Article
    3. Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives. Chen J, et al. Front Bioeng Biotechnol, 2023. PMID 36860883, Free PMC Article
    4. Experimental demonstration of tethered gene drive systems for confined population modification or suppression. Metzloff M, et al. BMC Biol, 2022 May 24. PMID 35606745, Free PMC Article
    5. Local Microtubule and F-Actin Distributions Fully Constrain the Spatial Geometry of Drosophila Sensory Dendritic Arbors. Nanda S, et al. Int J Mol Sci, 2023 Apr 4. PMID 37047715, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein L35A
    Names
    CG2099-PA
    RpL35A-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5465630..5467101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141282.3 → NP_649539.1  ribosomal protein L35A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNB9
      Related
      FBpp0078416
      Conserved Domains (1) summary
      pfam01247
      Location:50 → 150
      Ribosomal_L35Ae; Ribosomal protein L35Ae
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNB9 Q9VNB9

    Gene LinkOut

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