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    GstD2 Glutathione S transferase D2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48335, updated on 12-Dec-2024

    Summary

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    Official Symbol
    GstD2provided by FlyBase
    Official Full Name
    Glutathione S transferase D2provided by FlyBase
    Primary source
    FLYBASE:FBgn0010038
    Locus tag
    Dmel_CG4181
    See related
    AllianceGenome:FB:FBgn0010038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4181; Dmel\CG4181; DmGST21; DmGSTD2; gst; Gst; GST; Gst D2; GST D2; gst D21; GST-D2; gstd2; gstD2; GSTd2; GSTD2; gstd21; gstD21; Gstd21; GstD21
    Summary
    Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstD2 in Genome Data Viewer
    Location:
    87B8-87B8; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12371971..12372704)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8197693..8198426)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase D1 Neighboring gene long non-coding RNA:CR46015 Neighboring gene Glutathione S transferase D3 Neighboring gene Glutathione S transferase D4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of mRNA stability through a pentobarbital-responsive element. Akgül B, et al. Arch Biochem Biophys, 2007 Mar 1. PMID 17234150, Free PMC Article
    2. Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification. Gonzalez D, et al. Insect Biochem Mol Biol, 2018 Apr. PMID 29578047
    3. Pentobarbital-mediated regulation of alternative polyadenylation in Drosophila glutathione S-transferase D21 mRNAs. Akgül B, et al. J Biol Chem, 2004 Feb 6. PMID 14612442
    4. Biochemical characterization of Drosophila glutathione S-transferases D1 and D21. Tang AH, et al. J Biol Chem, 1994 Nov 11. PMID 7961718
    5. Pentobarbital-induced changes in Drosophila glutathione S-transferase D21 mRNA stability. Tang AH, et al. J Biol Chem, 1995 Jun 9. PMID 7775439

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase D2
    Names
    CG4181-PA
    GstD2-PA
    glutathione S transferase D21
    glutathione-S-transferase D2
    NP_524912.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12371971..12372704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080173.2 → NP_524912.1  glutathione S transferase D2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TX91, Q9VG98
      UniProtKB/TrEMBL
      H0RN92
      Related
      FBpp0082041
      Conserved Domains (2) summary
      cd03177
      Location:88 → 204
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      cd03045
      Location:1 → 74
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG98.1 Q9VG98

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