PK1-R Pyrokinin 1 receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PK1-Rprovided by FlyBase
Official Full Name: Pyrokinin 1 receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0038201
Locus tag: Dmel_CG9918
See related: AllianceGenome:FB:FBgn0038201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.112; anon-WO0170980.113; CG9918; Dmel\CG9918; LstR; Pk1r; Pk1R; PK1r; PK1R; pkr1
Summary: Enables pyrokinin receptor activity. Involved in negative regulation of peptide hormone secretion; neuropeptide signaling pathway; and triglyceride homeostasis. Located in plasma membrane. Used to study obesity. Orthologous to human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14099832..14103122, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9925554..9928844, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

CG9918 is a Drosophila pyrokinin-1 receptor
Title: The Drosophila gene CG9918 codes for a pyrokinin-1 receptor.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables pyrokinin receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG9918-PD; CG9918-PE; CPyrokinin 1 receptor; Drm-PK-1 receptor; Lst receptor; PK1-R-PD; PK1-R-PE; pyrokinin 1 R; pyrokinin receptor 1; pyrokinin-1 receptor

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The following sections contain reference sequences that belong to a specific genome build. Explain