ort ora transientless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ortprovided by FlyBase
Official Full Name: ora transientlessprovided by FlyBase
Primary source: FLYBASE:FBgn0003011
Locus tag: Dmel_CG7411
See related: AllianceGenome:FB:FBgn0003011
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7411; CT22815; Dm-hclA; Dmel\CG7411; DmHisCl2; DMHisClalpha1; GluCI; HA-CI I; hclA; HclA; HisC12; HisCI2; HisCl; HisCl-alpha1; hisCl2; HisCl2; Hist1; ora; Ort; ORT
Summary: Enables histamine-gated chloride channel activity. Involved in several processes, including adult behavior; chloride transport; and thermotaxis. Part of histamine-gated chloride channel complex. Is expressed in several structures, including adult optic lobe neurons; anterior-posterior subdivision of organism; brain; synaptic neuropil domain; and synaptic neuropil layer. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Orthologous to several human genes including GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 92A13-92A13; 3-66 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19659748..19663672)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15485470..15489394)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results show that both Ort and HisCl1 define two different pathways for circadian entrainment. Whereas Ort contributes through its expression in the interneurons of the optic lobe, HisCl1 mostly contributes through its expression in the Rh6-expressing retinal photoreceptors. The work thus reveals that Rh6-expressing neurons contribute to light-mediated entrainment as both photoreceptors and interneurons.
Title: The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles.
The native receptor at the synapse of large monopolar cells (LMC) is an hclA homomer that alone is necessary and sufficient to account for the native histamine receptors at the Drosophila photoreceptor-LMC synapse.
Title: Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse.
identified ort as a candidate gene encoding a histamine receptor subunit on laminar neurons, L1/L2
Title: The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA).

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables histamine-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables histamine-gated chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to ether	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histamine-gated chloride channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: ora transientless

Names: CG7411-PA; Histamine-gated chloride channel subunit 2; glycine receptor alpha2-like; histamine-gated chloride channel subunit 1; indefinite; ort-PA; outer rhabdomere absent; outer rhabdomeres absent; outer rhabdomeres transientless; outer-rhabdomeres-absent

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

19659748..19663672

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079682.3 → NP_524406.1 ora transientless [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524406.1

Status: REVIEWED

UniProtKB/TrEMBL

A1KYB3, A1KYB4, A1KYB5, Q9VDU9

Related

FBpp0083198

Conserved Domains (3) summary

TIGR00860
Location:31 → 481

LIC; Cation transporter family protein

pfam02931
Location:38 → 235

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:243 → 334

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region