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    CAH8 Carbonic anhydrase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAH8provided by FlyBase
    Official Full Name
    Carbonic anhydrase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0038956
    Locus tag
    Dmel_CG5379
    See related
    AllianceGenome:FB:FBgn0038956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5379; Dmel\CG5379
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult heart. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CAH8 in Genome Data Viewer
    Location:
    94A11-94A11; 3-74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22386489..22389714, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18212211..18215436, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glycerol-3-phosphate dehydrogenase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Serine-GCT 2-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
    2. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    4. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 8
    Names
    CAH8-PA
    CAH8-PB
    CG5379-PA
    CG5379-PB
    NP_001262833.1
    NP_651033.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22386489..22389714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275904.1 → NP_001262833.1  carbonic anhydrase 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4S9, Q9VD19
      Conserved Domains (1) summary
      smart01057
      Location:31 → 281
      Carb_anhydrase; Eukaryotic-type carbonic anhydrase

    2. NM_142776.4 → NP_651033.2  carbonic anhydrase 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651033.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4S9, Q9VD19
      Conserved Domains (1) summary
      smart01057
      Location:31 → 281
      Carb_anhydrase; Eukaryotic-type carbonic anhydrase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V4S9 Q4V4S9

    Gene LinkOut

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