bt bent [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: btprovided by FlyBase
Official Full Name: bentprovided by FlyBase
Primary source: FLYBASE:FBgn0005666
Locus tag: Dmel_CG32019
See related: AllianceGenome:FB:FBgn0005666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 39c-18; Bt; CG10285; CG1479; CG32019; CT3598; CT8086; Dmel\CG32019; l(2)2; l(2)23; l(4)102CDa; l(4)2; l(4)21; l(4)23; l(4)37; l(4)38; l(4)PT-2; Prj; projectin; titin
Summary: Enables protein kinase activity. A structural constituent of muscle. Involved in mesoderm development; muscle thin filament assembly; and sarcomere organization. Located in Z disc. Is expressed in several structures, including adult head; adult heart; border follicle cell; muscle cell; and muscle system. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to several human genes including TTN (titin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102D5-102E1; 4-0 cM

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (724400..776474)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (745026..797100)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Projectin immunolocalization studies during myofibrillogenesis in Drosophila indirect flight muscles.
Title: Assembly of the giant protein projectin during myofibrillogenesis in Drosophila indirect flight muscles.
isoforms and alternative splicing of PEVK-like region
Title: Alternative splicing of an amino-terminal PEVK-like region generates multiple isoforms of Drosophila projectin.
Projectin is oriented within the indirect flight muscles sarcomere with its NH2-terminus embedded in the Z-bands. This protein has an elastic region, possibly the PEVK-like domain located close to the NH2-terminus.
Title: In indirect flight muscles Drosophila projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 729819-730256 mobile_element_type = transposon:INE-1{}1980
Loc: 749321-749642 mobile_element_type = transposon:INE-1{}2051
Loc: 749972-750190 mobile_element_type = transposon:INE-1{}2053
Loc: 751516-751635 mobile_element_type = transposon:INE-1{}2073
Loc: 757191-757463 mobile_element_type = transposon:INE-1{}2074
Loc: 773208-773805 mobile_element_type = transposon:Tc1{}1529

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables structural constituent of muscle	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle thin filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bent

Names: C-protein; CG32019-PC; CG32019-PF; CG32019-PH; CG32019-PI; CG32019-PJ; bt-PC; bt-PF; bt-PH; bt-PI; bt-PJ; lethal(4) Powell, Tennessee-2; myosin LCK; projectin; projectin myosin light chain kinase; twitchin

NP_001162825.1

EC 2.7.11.1

NP_001259071.1

EC 2.7.11.1

NP_001259072.1

EC 2.7.11.1

NP_001284716.1

EC 2.7.11.1

NP_995598.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

724400..776474

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272143.2 → NP_001259072.1 bent, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259072.1

Status: REVIEWED

UniProtKB/TrEMBL

L0MN91

Conserved Domains (10) summary

cd00096
Location:7205 → 7272

Ig; Immunoglobulin domain

cd05748
Location:6115 → 6188

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:8579 → 8644

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7922 → 8177

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:4922 → 5002

IG; Immunoglobulin

smart00410
Location:1436 → 1521

IG_like; Immunoglobulin like

cd00063
Location:6292 → 6384

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:8565 → 8654

I-set; Immunoglobulin I-set domain

cd14114
Location:7919 → 8177

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3449 → 3523

Ig; Immunoglobulin domain
NM_001169354.2 → NP_001162825.1 bent, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162825.1

Status: REVIEWED

UniProtKB/TrEMBL

D1YSG0

Conserved Domains (10) summary

cd00096
Location:7272 → 7339

Ig; Immunoglobulin domain

cd05748
Location:6182 → 6255

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:8646 → 8711

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7989 → 8244

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:4989 → 5069

IG; Immunoglobulin

smart00410
Location:1503 → 1588

IG_like; Immunoglobulin like

cd00063
Location:6359 → 6451

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:8632 → 8721

I-set; Immunoglobulin I-set domain

cd14114
Location:7986 → 8244

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3516 → 3590

Ig; Immunoglobulin domain
NM_205876.3 → NP_995598.1 bent, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995598.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KQP6

Conserved Domains (10) summary

cd00096
Location:6987 → 7054

Ig; Immunoglobulin domain

cd05748
Location:5897 → 5970

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:8361 → 8426

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7704 → 7959

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:4704 → 4784

IG; Immunoglobulin

smart00410
Location:7069 → 7155

IG_like; Immunoglobulin like

cd00063
Location:6074 → 6166

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:8347 → 8436

I-set; Immunoglobulin I-set domain

cd14114
Location:7701 → 7959

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3231 → 3305

Ig; Immunoglobulin domain
NM_001297787.1 → NP_001284716.1 bent, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284716.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JD89

Conserved Domains (10) summary

cd00096
Location:6941 → 7008

Ig; Immunoglobulin domain

cd05748
Location:5851 → 5924

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:8315 → 8380

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7658 → 7913

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:4658 → 4738

IG; Immunoglobulin

smart00410
Location:7023 → 7109

IG_like; Immunoglobulin like

cd00063
Location:6028 → 6120

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:8301 → 8390

I-set; Immunoglobulin I-set domain

cd14114
Location:7655 → 7913

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3185 → 3259

Ig; Immunoglobulin domain
NM_001272142.1 → NP_001259071.1 bent, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259071.1

Status: REVIEWED

UniProtKB/TrEMBL

L0MPZ1

Conserved Domains (10) summary

cd00096
Location:6766 → 6833

Ig; Immunoglobulin domain

cd05748
Location:5676 → 5749

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:8121 → 8186

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7483 → 7738

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:4483 → 4563

IG; Immunoglobulin

smart00410
Location:6848 → 6934

IG_like; Immunoglobulin like

cd00063
Location:5853 → 5945

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:8107 → 8196

I-set; Immunoglobulin I-set domain

cd14114
Location:7480 → 7738

STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin

cl11960
Location:3010 → 3084

Ig; Immunoglobulin domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
D1YSG0		D1YSG0
L0MN91		L0MN91
L0MPZ1		L0MPZ1
O76280		O76280
O76281		O76281
Q24463		Q24463
Q7KQP6		Q7KQP6
Q8MZ51		Q8MZ51
Q8ST85		Q8ST85
Q961U1		Q961U1
X2JD89		X2JD89