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    SLO2 slowpoke 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLO2provided by FlyBase
    Official Full Name
    slowpoke 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0261698
    Locus tag
    Dmel_CG42732
    See related
    AllianceGenome:FB:FBgn0261698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12897; CG12899; CG12901; CG12904; CG34363; CG42732; Dmel\CG42732; Dm_2R:24301; Dm_2R:24438; dSlo2; dSLO2; Slack; Slo2
    Old locus tag
    CG12899; CG12904; Dmel_CG12897; Dmel_CG12899; Dmel_CG12904; Dmel_CG34363
    Summary
    Enables intracellular sodium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SLO2 in Genome Data Viewer
    Location:
    47A1-47A7; 2-62 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10322195..10416996, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6209700..6304501, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 46a Neighboring gene uncharacterized protein Neighboring gene Nidogen Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 47a Neighboring gene Ionotropic receptor 47b Neighboring gene Ionotropic receptor 47a Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels. Budelli G, et al. J Biol Chem, 2016 Apr 1. PMID 26823461, Free PMC Article
    2. Slo2/K(Na) Channels in Drosophila Protect against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na(+) Current. Byers N, et al. J Neurosci, 2021 Oct 27. PMID 34544836, Free PMC Article
    3. Diurnal protein oscillation profiles in Drosophila head. Du J, et al. FEBS Lett, 2018 Nov. PMID 30311939, Free PMC Article
    4. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. McCormack TJ. Genome Biol, 2003. PMID 12952537, Free PMC Article
    5. Evolution of secretin family GPCR members in the metazoa. Cardoso JC, et al. BMC Evol Biol, 2006 Dec 13. PMID 17166275, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slo2/KNa Channels in Drosophila Protect against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na(+) Current.
      Title: Slo2/K(Na) Channels in Drosophila Protect against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na(+) Current.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intracellular sodium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellular sodium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    slowpoke 2
    Names
    CG42732-PD
    CG42732-PE
    CG42732-PF
    CG42732-PG
    CG42732-PH
    CG42732-PI
    CG42732-PL
    CG42732-PN
    CG42732-PO
    SLO2-PD
    SLO2-PE
    SLO2-PF
    SLO2-PG
    SLO2-PH
    SLO2-PI
    SLO2-PL
    SLO2-PN
    SLO2-PO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10322195..10416996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273934.1 → NP_001260863.1  slowpoke 2, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF87
      Conserved Domains (2) summary
      pfam03493
      Location:507 → 602
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:302 → 346
      Ion_trans_2; Ion channel

    2. NM_001273933.1 → NP_001260862.1  slowpoke 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFK3
      Conserved Domains (2) summary
      pfam03493
      Location:461 → 556
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:256 → 300
      Ion_trans_2; Ion channel

    3. NM_001259313.2 → NP_001246242.1  slowpoke 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K738, A0A165TJ88
      Conserved Domains (2) summary
      pfam03493
      Location:457 → 552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252 → 296
      Ion_trans_2; Ion channel

    4. NM_001201972.3 → NP_001188901.1  slowpoke 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHC4
      Conserved Domains (2) summary
      pfam03493
      Location:457 → 552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252 → 296
      Ion_trans_2; Ion channel

    5. NM_001273932.1 → NP_001260861.1  slowpoke 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEQ3
      Conserved Domains (2) summary
      pfam03493
      Location:457 → 552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252 → 296
      Ion_trans_2; Ion channel

    6. NM_001273935.1 → NP_001260864.1  slowpoke 2, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEJ9
      Conserved Domains (2) summary
      pfam03493
      Location:457 → 552
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252 → 296
      Ion_trans_2; Ion channel

    7. NM_001103788.3 → NP_001097258.2  slowpoke 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097258.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY94
      Conserved Domains (2) summary
      pfam03493
      Location:524 → 619
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:297 → 363
      Ion_trans_2; Ion channel

    8. NM_001103789.3 → NP_001097259.2  slowpoke 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097259.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY93
      Conserved Domains (2) summary
      pfam03493
      Location:524 → 619
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:297 → 363
      Ion_trans_2; Ion channel

    9. NM_001201971.2 → NP_001188900.1  slowpoke 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188900.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD38
      Conserved Domains (2) summary
      pfam03493
      Location:538 → 633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:311 → 377
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD38 A0A0B4JD38
    A0A0B4K738 A0A0B4K738
    A0A0B4KEJ9 A0A0B4KEJ9
    A0A0B4KEQ3 A0A0B4KEQ3
    A0A0B4KF87 A0A0B4KF87
    A0A0B4KFK3 A0A0B4KFK3
    A0A0C4DHC4 A0A0C4DHC4
    A8DY93 A8DY93
    A8DY94 A8DY94

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