Su(dx) Suppressor of deltex [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(dx)provided by FlyBase
Official Full Name: Suppressor of deltexprovided by FlyBase
Primary source: FLYBASE:FBgn0003557
Locus tag: Dmel_CG4244
See related: AllianceGenome:FB:FBgn0003557
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AIP4; anon-WO0073329.1; anon-WO0073329.2; anon-WO0073329.4; CG4244; Dmel\CG4244; Itch; ITCH; Su (Dx); Su(deltex); su(dx); Su(Dx); Su(DX); sudx
Summary: Enables Notch binding activity and ubiquitin protein ligase activity. Involved in several processes, including R8 cell development; instar larval or pupal development; and negative regulation of signal transduction. Located in cell cortex. Is expressed in adult head and wing. Orthologous to several human genes including WWP1 (WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 22C1-22C1; 2-4 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2037714..2044372)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2037714..2044372)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Su(dx) acts as a negative regulator of Pez. Overexpression of Su(dx) induces proliferation in the midgut epithelium, which can be rescued by overexpressed Pez.
Title: Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis.
Study identified a network of competing endocytic routes mediated by Su(dx) and Dx that positively and negatively regulate N activation; have distinct requirements for ligands, membrane sterol, and endosomal trafficking components; and have different temperature sensitivities.
Title: Compensatory flux changes within an endocytic trafficking network maintain thermal robustness of Notch signaling.
A core antagonistic interaction between Pyd and the WW domain E3 ubiquitin ligase Su(dx), was identified.
Title: Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue.
Su(dx) regulates the level of Notch signalling in vivo, upstream of Notch target genes and in different developmental contexts, including a previously unknown role in leg joint formation
Title: Down-regulation of Notch target gene expression by Suppressor of deltex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to lysosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in pupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: suppressor of deltex

Names: CG4244-PA; CG4244-PB; CG4244-PC; CG4244-PE; CG4244-PF; Su(dx)-PA; Su(dx)-PB; Su(dx)-PC; Su(dx)-PE; Su(dx)-PF; supressor of deltex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2037714..2044372

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164448.2 → NP_722753.1 suppressor of deltex, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722753.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZZ3, Q0E8U5, Q8T0C8, Q9Y0H4

UniProtKB/TrEMBL

B7YZY9

Related

FBpp0077496

Conserved Domains (5) summary

cd04021
Location:48 → 173

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00456
Location:478 → 509

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:620 → 946

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:594 → 946

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:397 → 426

WW; WW domain
NM_057405.3 → NP_476753.1 suppressor of deltex, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476753.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZZ3, Q0E8U5, Q8T0C8, Q9Y0H4

UniProtKB/TrEMBL

B7YZY9

Related

FBpp0077495

Conserved Domains (5) summary

cd04021
Location:48 → 173

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00456
Location:478 → 509

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:620 → 946

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:594 → 946

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:397 → 426

WW; WW domain
NM_001272969.1 → NP_001259898.1 suppressor of deltex, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259898.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZZ3, Q0E8U5, Q8T0C8, Q9Y0H4

UniProtKB/TrEMBL

B7YZY9

Conserved Domains (5) summary

cd04021
Location:48 → 173

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00456
Location:478 → 509

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:620 → 946

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:594 → 946

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:397 → 426

WW; WW domain
NM_001272970.1 → NP_001259899.1 suppressor of deltex, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259899.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZZ3, Q0E8U5, Q8T0C8, Q9Y0H4

UniProtKB/TrEMBL

B7YZY9

Conserved Domains (5) summary

cd04021
Location:48 → 173

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00456
Location:478 → 509

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:620 → 946

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:594 → 946

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:397 → 426

WW; WW domain
NM_164449.2 → NP_722754.1 suppressor of deltex, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722754.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZZ3, Q0E8U5, Q8T0C8, Q9Y0H4

UniProtKB/TrEMBL

B7YZY9

Related

FBpp0077497

Conserved Domains (5) summary

cd04021
Location:48 → 173

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00456
Location:478 → 509

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:620 → 946

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:594 → 946

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:397 → 426

WW; WW domain