E(spl)mbeta-HLH Enhancer of split mbeta, helix-loop-helix [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: E(spl)mbeta-HLHprovided by FlyBase
Official Full Name: Enhancer of split mbeta, helix-loop-helixprovided by FlyBase
Primary source: FLYBASE:FBgn0002733
Locus tag: Dmel_CG14548
See related: AllianceGenome:FB:FBgn0002733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLHb34; CG14548; Dm-mA; Dmel\CG14548; E(spl); E(Spl) HLH-Mbeta; E(spl) mbeta; E(spl)-mbeta; E(spl)-Mbeta; E(spl)beta; E(spl)mA; E(spl)mb; E(spl)mbeta; E(spl)Mbeta; E(Spl)mbeta; HLH-mbeta; HLHm beta; HLHmA; HLHmbeta; HLHMbeta; m-beta; mA; mb; mbeta; Mbeta
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuroblast proliferation. Acts upstream of with a negative effect on chaeta development. Located in nucleus. Is expressed in several structures, including gut section; head epidermis primordium; imaginal disc; organism subdivision; and visceral mesoderm derivative. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

See E(spl)mbeta-HLH in Genome Data Viewer

Location:: 96F9-96F9; 3-89 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26005046..26006023, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21830768..21831745, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The proliferation and differentiation of intestinal stem cells are not regulated by individual Notch downstream target E(spl)mbeta, but by different downstream targets collectively.
Title: Notch signaling downstream target E(spl)mbeta is dispensable for adult midgut homeostasis in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_negative_effect chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: enhancer of split mbeta, helix-loop-helix

Names: CG14548-PA; E(spl) region transcript mbeta; E(spl)mbeta-HLH-PA; enhancer of split m-beta; enhancer of split mbeta; enhancer of split region transcript HLHmA; split locus enhancer protein mA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

26005046..26006023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079781.3 → NP_524505.2 enhancer of split mbeta, helix-loop-helix [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524505.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q01069, Q01906, Q540X9, Q5S4K3, Q9VBJ0

Related

FBpp0084355

Conserved Domains (2) summary

smart00511
Location:97 → 141

ORANGE; Orange domain

cd00083
Location:13 → 75

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...