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    Hpd 4-hydroxyphenylpyruvate dioxygenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hpdprovided by FlyBase
    Official Full Name
    4-hydroxyphenylpyruvate dioxygenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036992
    Locus tag
    Dmel_CG11796
    See related
    AllianceGenome:FB:FBgn0036992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11796; Dmel\CG11796; HPD
    Summary
    Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in adult head; embryonic dorsal epidermis; and embryonic ventral epidermis. Used to study tyrosinemia type III. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hpd in Genome Data Viewer
    Location:
    77C3-77C3; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20438166..20439872, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20431266..20432972, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Lipoic acid synthase Neighboring gene Presenilin Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene CTBP-interacting protein Neighboring gene long non-coding RNA:CR45176 Neighboring gene long non-coding RNA:CR43943 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain. Belfiori-Carrasco LF, et al. Front Aging Neurosci, 2017. PMID 28352227, Free PMC Article
    2. Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila. Kosakamoto H, et al. Development, 2024 Jan 1. PMID 38165175
    3. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
    4. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
    5. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Grönke S, et al. Cell Metab, 2005 May. PMID 16054079

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4-hydroxyphenylpyruvate dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-hydroxyphenylpyruvate dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    4-hydroxyphenylpyruvate dioxygenase
    Names
    CG11796-PA
    CG11796-PB
    Hpd-PA
    Hpd-PB
    NP_649225.1
    NP_730536.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20438166..20439872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168857.3 → NP_730536.1  4-hydroxyphenylpyruvate dioxygenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPF3, Q9VPF4
      Related
      FBpp0077883
      Conserved Domains (1) summary
      TIGR01263
      Location:17 → 380
      4HPPD; 4-hydroxyphenylpyruvate dioxygenase

    2. NM_140968.4 → NP_649225.1  4-hydroxyphenylpyruvate dioxygenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649225.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961W1
      Related
      FBpp0077884
      Conserved Domains (3) summary
      cd07250
      Location:91 → 286
      HPPD_C_like; C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
      cd08342
      Location:1 → 75
      HPPD_N_like; N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
      TIGR01263
      Location:1 → 294
      4HPPD; 4-hydroxyphenylpyruvate dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961W1 Q961W1
    Q9VPF3 Q9VPF3

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