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    und uninitiated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    undprovided by FlyBase
    Official Full Name
    uninitiatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283478
    Locus tag
    Dmel_CG4008
    See related
    AllianceGenome:FB:FBgn0283478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4008; DMAP2; Dmel\CG4008; MAP2; p67
    Summary
    Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; endoderm anlage; gut section; and mesoderm. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See und in Genome Data Viewer
    Location:
    30C7-30C7; 2-36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9763369..9765338)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9763369..9765338)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene zinc finger protein 30C Neighboring gene TBP-associated factor 11 Neighboring gene pickpocket 18 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A methionine aminopeptidase and putative regulator of translation initiation is required for cell growth and patterning in Drosophila. Cutforth T, et al. Mech Dev, 1999 Apr. PMID 10354468
    2. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms. Giglione C, et al. EMBO J, 2000 Nov 1. PMID 11060042, Free PMC Article
    3. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
    4. Ancient Male Recombination Shaped Genetic Diversity of Neo-Y Chromosome in Drosophila albomicans. Satomura K, et al. Mol Biol Evol, 2016 Feb. PMID 26494844
    5. Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells in Drosophila. Earl JB, et al. G3 (Bethesda), 2020 Nov 5. PMID 32972998, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloexopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uninitiated
    Names
    CG4008-PA
    CG4008-PB
    CG4008-PC
    p67
    und-PA
    und-PB
    und-PC
    NP_001260299.1
    NP_001285783.1
    NP_477373.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9763369..9765338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058025.5 → NP_477373.1  uninitiated, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61540, Q9VL89
      Related
      FBpp0079462
      Conserved Domains (1) summary
      PTZ00053
      Location:79 → 448
      PTZ00053; methionine aminopeptidase 2; Provisional

    2. NM_001298854.1 → NP_001285783.1  uninitiated, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61540, Q9VL89
      Conserved Domains (1) summary
      PTZ00053
      Location:79 → 448
      PTZ00053; methionine aminopeptidase 2; Provisional

    3. NM_001273370.2 → NP_001260299.1  uninitiated, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260299.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61540, Q9VL89
      Conserved Domains (1) summary
      PTZ00053
      Location:79 → 448
      PTZ00053; methionine aminopeptidase 2; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61540 O61540
    Q9VL89 Q9VL89

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