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    RanBPM Ran-binding protein M [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RanBPMprovided by FlyBase
    Official Full Name
    Ran-binding protein Mprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262114
    Locus tag
    Dmel_CG42236
    See related
    AllianceGenome:FB:FBgn0262114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11763; CG42236; Dmel\CG42236; l(2)k05201
    Old locus tag
    Dmel_CG11763
    Summary
    Predicted to enable small GTPase binding activity. Involved in several processes, including dorsal appendage formation; follicle cell of egg chamber-cell adhesion; and germ-line stem-cell niche homeostasis. Located in cytoplasm; membrane; and nucleus. Part of GID complex. Is expressed in several structures, including adult head; germline cell; larval ventral nerve cord; ovary; and somatic cell of ovariole. Orthologous to several human genes including RANBP9 (RAN binding protein 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RanBPM in Genome Data Viewer
    Location:
    47A7-47A7; 2-62 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10429708..10436581)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6317213..6324086)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Peroxiredoxin 6b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior. Scantlebury N, et al. PLoS One, 2010 May 14. PMID 20498842, Free PMC Article
    2. RanBPM regulates cell shape, arrangement, and capacity of the female germline stem cell niche in Drosophila melanogaster. Dansereau DA, et al. J Cell Biol, 2008 Sep 8. PMID 18762575, Free PMC Article
    3. The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition. Zavortink M, et al. Elife, 2020 Jun 23. PMID 32573431, Free PMC Article
    4. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Baeg GH, et al. Genes Dev, 2005 Aug 15. PMID 16055650, Free PMC Article
    5. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ran-binding protein M
    Names
    CG42236-PA
    CG42236-PC
    CG42236-PD
    CG42236-PE
    CG42236-PF
    CG42236-PG
    Ran binding protein M
    Ran-Binding protein in the microtubule organizing center
    Ran-binding proteins 9/10 homologue
    RanBPM-PA
    RanBPM-PC
    RanBPM-PD
    RanBPM-PE
    RanBPM-PF
    RanBPM-PG
    lethal (2) k05201

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10429708..10436581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165770.3 → NP_724932.1  Ran-binding protein M, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IY22
      Related
      FBpp0087358
      Conserved Domains (5) summary
      smart00668
      Location:655 → 711
      CTLH; C-terminal to LisH motif
      smart00757
      Location:846 → 944
      CRA; CT11-RanBPM
      pfam04554
      Location:55 → 103
      Extensin_2; Extensin-like region
      pfam10607
      Location:655 → 938
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:442 → 584
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    2. NM_001316413.1 → NP_001303342.1  Ran-binding protein M, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUM4, C4IY22
      Conserved Domains (6) summary
      smart00668
      Location:655 → 711
      CTLH; C-terminal to LisH motif
      smart00757
      Location:846 → 944
      CRA; CT11-RanBPM
      pfam04554
      Location:55 → 103
      Extensin_2; Extensin-like region
      pfam06994
      Location:137 → 188
      Involucrin2; Involucrin
      pfam10607
      Location:655 → 938
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:442 → 584
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    3. NM_001259326.1 → NP_001246255.1  Ran-binding protein M, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246255.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K851, C4IY22
      Conserved Domains (5) summary
      smart00668
      Location:656 → 712
      CTLH; C-terminal to LisH motif
      smart00757
      Location:847 → 945
      CRA; CT11-RanBPM
      pfam04554
      Location:55 → 103
      Extensin_2; Extensin-like region
      pfam10607
      Location:656 → 939
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:442 → 585
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    4. NM_001038849.2 → NP_001033938.1  Ran-binding protein M, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z895, A1Z896, A8E757, Q4Z8K6, Q6NN33, Q8T0U5, Q960F3
      UniProtKB/TrEMBL
      C4IY22
      Conserved Domains (5) summary
      smart00668
      Location:655 → 711
      CTLH; C-terminal to LisH motif
      smart00757
      Location:848 → 946
      CRA; CT11-RanBPM
      pfam04554
      Location:55 → 103
      Extensin_2; Extensin-like region
      pfam10607
      Location:655 → 940
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:442 → 584
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    5. NM_136741.3 → NP_610585.2  Ran-binding protein M, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610585.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5D3H6
      Related
      FBpp0087357
      Conserved Domains (5) summary
      smart00667
      Location:256 → 279
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:293 → 349
      CTLH; C-terminal to LisH motif
      smart00757
      Location:484 → 582
      CRA; CT11-RanBPM
      pfam10607
      Location:293 → 576
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:80 → 222
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    6. NM_001273938.1 → NP_001260867.1  Ran-binding protein M, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFL0
      Conserved Domains (5) summary
      smart00667
      Location:256 → 279
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:293 → 349
      CTLH; C-terminal to LisH motif
      smart00757
      Location:489 → 587
      CRA; CT11-RanBPM
      pfam10607
      Location:293 → 581
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:80 → 222
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K851 A0A0B4K851
    A0A0B4KFL0 A0A0B4KFL0
    A0A126GUM4 A0A126GUM4
    Q4Z8K6.1 Q4Z8K6

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