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    eIF4H2 eukaryotic translation initiation factor 4H2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF4H2provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4H2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039797
    Locus tag
    Dmel_CG1340
    See related
    AllianceGenome:FB:FBgn0039797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg1340; CG1340; Dmel\CG1340; eIF4H; EIF4H2
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF4H2 in Genome Data Viewer
    Location:
    100A3-100A3; 3-101 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30726087..30728052)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26551809..26553774)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46219 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift. Cingolani P, et al. Front Genet, 2012. PMID 22435069, Free PMC Article
    2. DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation. Linsalata AE, et al. EMBO Rep, 2019 Sep. PMID 31347257, Free PMC Article
    3. The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing. Labourier E, et al. Genes Dev, 2002 Jan 1. PMID 11782446, Free PMC Article
    4. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article
    5. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. Dembeck LM, et al. PLoS Genet, 2015 May. PMID 25933381, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4H2
    Names
    CG1340-PA
    CG1340-PC
    eIF4H2-PA
    eIF4H2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30726087..30728052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276193.1 → NP_001263122.1  eukaryotic translation initiation factor 4H2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263122.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHF2, Q9VA45
      Conserved Domains (2) summary
      COG0724
      Location:58 → 247
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:62 → 140
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_143563.3 → NP_651820.1  eukaryotic translation initiation factor 4H2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHF2, Q9VA45
      Related
      FBpp0085061
      Conserved Domains (2) summary
      COG0724
      Location:58 → 247
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:62 → 140
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IHF2 Q8IHF2
    Q8MSI8 Q8MSI8
    Q9VA45 Q9VA45

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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