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    Zn72D Zinc-finger protein at 72D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zn72Dprovided by FlyBase
    Official Full Name
    Zinc-finger protein at 72Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263603
    Locus tag
    Dmel_CG5215
    See related
    AllianceGenome:FB:FBgn0263603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5215; Dmel\CG5215; l(3)72Dk; zn72D; ZN72D
    Summary
    Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and sensory nervous system primordium. Orthologous to several human genes including ZFR (zinc finger RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zn72D in Genome Data Viewer
    Location:
    72D6-72D7; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16106594..16112626, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16099694..16105726, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Isoleucyl-tRNA synthetase, mitochondrial Neighboring gene Integrator 9 Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 4 Neighboring gene Strumpellin Neighboring gene Phosphoglucose mutase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new function of immunity-related gene Zn72D in male fertility of Drosophila melanogaster. Biwot JC, et al. Arch Insect Biochem Physiol, 2019 Dec. PMID 31482645
    2. Wolbachia-induced expression of kenny gene in testes affects male fertility in Drosophila melanogaster. Biwot JC, et al. Insect Sci, 2020 Oct. PMID 31617302
    3. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, et al. Nat Genet, 2018 Jan. PMID 29273807, Free PMC Article
    4. Zinc finger protein Zn72D promotes productive splicing of the maleless transcript. Worringer KA, et al. Mol Cell Biol, 2007 Dec. PMID 17923683, Free PMC Article
    5. An inducible nuclear body in the Drosophila germinal vesicle. Singer AB, et al. Nucleus, 2011 Sep-Oct. PMID 21941118, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
      Title: Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
    2. Zn72D may have an important function in spermatogenesis by sustaining the cytoskeleton-based morphogenesis and individualization thus ensuring the proper formation of sperm in D. melanogaster.
      Title: A new function of immunity-related gene Zn72D in male fertility of Drosophila melanogaster.
    3. Zn72D and Bel work together to control maleless splicing and protein levels
      Title: The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels.
    4. Zn72D is required for productive splicing of the transcript for the MSL protein Maleless, explaining the dosage compensation defect.
      Title: Zinc finger protein Zn72D promotes productive splicing of the maleless transcript.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    Zinc-finger protein at 72D
    Names
    CG5215-PA
    CG5215-PB
    CG5215-PC
    CG5215-PD
    CG5215-PE
    CG5215-PF
    Zn72D-PA
    Zn72D-PB
    Zn72D-PC
    Zn72D-PD
    Zn72D-PE
    Zn72D-PF
    lethal (3) 72Dk

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16106594..16112626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274995.1 → NP_001261924.1  Zinc-finger protein at 72D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BI3
      Conserved Domains (3) summary
      smart00572
      Location:577 → 829
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:252 → 284
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:207 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001274996.1 → NP_001261925.1  Zinc-finger protein at 72D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261925.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BI3
      Conserved Domains (3) summary
      smart00572
      Location:577 → 829
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:252 → 284
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:207 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_176332.2 → NP_788510.1  Zinc-finger protein at 72D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BI3
      Related
      FBpp0075249
      Conserved Domains (3) summary
      smart00572
      Location:577 → 829
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:252 → 284
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:207 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_140582.3 → NP_648839.1  Zinc-finger protein at 72D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648839.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94540, Q95U26, Q9VUY6
      Related
      FBpp0075248
      Conserved Domains (3) summary
      smart00451
      Location:252 → 284
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:207 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02675
      Location:577 → 631
      DZF; DZF domain

    5. NM_001274994.1 → NP_001261923.1  Zinc-finger protein at 72D, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAG2, Q94540
      Conserved Domains (3) summary
      smart00451
      Location:252 → 284
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:207 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02675
      Location:577 → 631
      DZF; DZF domain

    6. NM_001274997.1 → NP_001261926.1  Zinc-finger protein at 72D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BI3
      Conserved Domains (3) summary
      smart00572
      Location:577 → 829
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:252 → 284
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:207 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F0JAG2 F0JAG2
    Q86BI3 Q86BI3
    Q94540 Q94540
    Q9VUY6 Q9VUY6

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