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    SdhA Succinate dehydrogenase, subunit A (flavoprotein) [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37228, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SdhAprovided by FlyBase
    Official Full Name
    Succinate dehydrogenase, subunit A (flavoprotein)provided by FlyBase
    Primary source
    FLYBASE:FBgn0261439
    Locus tag
    Dmel_CG17246
    See related
    AllianceGenome:FB:FBgn0261439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2R1; CG17246; DHSA; Dmel\CG17246; dSDHA; scs-fp; Scs-fp; sdh; Sdh; SDH; Sdh A; sdhA; Sdha
    Summary
    Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Involved in electron transport chain. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and larval muscle cell. Used to study mitochondrial complex II deficiency. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SdhA in Genome Data Viewer
    Location:
    56D3-56D3; 2-89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19391863..19395971, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15279368..15283476, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45925 Neighboring gene antisense RNA:CR43430 Neighboring gene crammer Neighboring gene hu li tai shao

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapamycin as a potential treatment for succinate dehydrogenase deficiency. Fan F, et al. Heliyon, 2019 Feb. PMID 30805566, Free PMC Article
    2. A general cell marker for clonal analysis of Drosophila development. Lawrence PA. J Embryol Exp Morphol, 1981 Aug. PMID 6947038
    3. Model systems in SDHx-related pheochromocytoma/paraganglioma. Takács-Vellai K, et al. Cancer Metastasis Rev, 2021 Dec. PMID 34957538, Free PMC Article
    4. Drosophila long-term memory formation involves regulation of cathepsin activity. Comas D, et al. Nature, 2004 Jul 22. PMID 15269770
    5. Reactive oxygen species act remotely to cause synapse loss in a Drosophila model of developmental mitochondrial encephalopathy. Mast JD, et al. Development, 2008 Aug. PMID 18599508, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in respiratory electron transport chain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in succinate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex II (succinate dehydrogenase) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex II (succinate dehydrogenase) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate dehydrogenase, subunit A (flavoprotein)
    Names
    CG17246-PA
    CG17246-PB
    CG17246-PC
    COMPLEX II: flavoprotein subunit
    SUCCINYL COENZIME A SYNTHETASE FLAVOPROTEIN SUBUNIT
    SdhA-PA
    SdhA-PB
    SdhA-PC
    succinate dehydrogenase
    succinate dehydrogenase A
    succinate dehydrogenase [ubiquinone] flavoprotein subunit
    succinate dehydrogenase flavoprotein
    succinate dehydrogenase flavoprotein subunit
    succinyl CoA synthetase flavoprotein subunit of complex II
    succinyl coenzyme A synthetase flavoprotein subunit
    NP_477210.1
    NP_725881.1
    NP_725882.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19391863..19395971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166343.3 → NP_725881.1  succinate dehydrogenase, subunit A (flavoprotein), isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZP5, C7LA77, Q0E918, Q94523, Q9I7G3
      Related
      FBpp0085736
      Conserved Domains (3) summary
      PTZ00139
      Location:49 → 661
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:511 → 661
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:80 → 469
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_166344.3 → NP_725882.1  succinate dehydrogenase, subunit A (flavoprotein), isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725882.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZP5, C7LA77, Q0E918, Q94523, Q9I7G3
      Related
      FBpp0085738
      Conserved Domains (3) summary
      PTZ00139
      Location:49 → 661
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:511 → 661
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:80 → 469
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_057862.5 → NP_477210.1  succinate dehydrogenase, subunit A (flavoprotein), isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477210.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZP5, C7LA77, Q0E918, Q94523, Q9I7G3
      Related
      FBpp0085737
      Conserved Domains (3) summary
      PTZ00139
      Location:49 → 661
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:511 → 661
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:80 → 469
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94523.3 Q94523

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