U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dad Daughters against dpp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42059, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dadprovided by FlyBase
    Official Full Name
    Daughters against dppprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020493
    Locus tag
    Dmel_CG5201
    See related
    AllianceGenome:FB:FBgn0020493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1883; anon-EST:fe1F5; CG5201; dad; DAD; Dmel\CG5201; EP(3)3196; EP3196; l(3)j1E4; Smad7
    Summary
    Enables BMP receptor binding activity. Involved in several processes, including imaginal disc morphogenesis; intestinal stem cell homeostasis; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including adult pacemaker neurons; follicle cell; germline cell; gut section; and larval imaginal tissue. Human ortholog(s) of this gene implicated in aortic valve disease 2; colorectal cancer; craniosynostosis 7; pancreatic adenocarcinoma; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dad in Genome Data Viewer
    Location:
    89E11-89E11; 3-59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17054007..17070408)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12879729..12896130)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene bedwarfed Neighboring gene Protein associated with topo II related - 1 Neighboring gene Nucleostemin 1 Neighboring gene mitochondrial ribosomal protein S11

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Bone morphogenetic protein- and mating-dependent secretory cell growth and migration in the Drosophila accessory gland. Leiblich A, et al. Proc Natl Acad Sci U S A, 2012 Nov 20. PMID 23129615, Free PMC Article
    2. Application of the 3C Method to Study the Developmental Genes in Drosophila Larvae. Bylino OV, et al. Front Genet, 2022. PMID 35910225, Free PMC Article
    3. Transcriptional programs are activated and microRNAs are repressed within minutes after mating in the Drosophila melanogaster female reproductive tract. Delbare SYN, et al. BMC Genomics, 2023 Jun 27. PMID 37370014, Free PMC Article
    4. Tissue Crowding Induces Caspase-Dependent Competition for Space. Levayer R, et al. Curr Biol, 2016 Mar 7. PMID 26898471, Free PMC Article
    5. Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid. Wainwright SM, et al. Proc Natl Acad Sci U S A, 2021 Feb 2. PMID 33495334, Free PMC Article

    See all (366) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dad associates with the cellular membrane via palmitoylation. Cys556 is essential for Dad palmitoylation and membrane association.
      Title: Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling.
    2. Dad and Dpp activity is dynamically regulated in the adult Drosophila middle midgut. Dynamic regulation of Dad is required for gastric stem cell differentiation.
      Title: Ubx dynamically regulates Dpp signaling by repressing Dad expression during copper cell regeneration in the adult Drosophila midgut.
    3. Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad.
      Title: Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad.
    4. Dad inhibited Saxophone and Thickveins but not Baboon.
      Title: Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.
    5. Dad is an inhibitor of dpp.
      Title: The role of Dpp and its inhibitors during eggshell patterning in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables BMP receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription regulator inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anterior/posterior pattern specification, imaginal disc IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell elongation involved in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye-antennal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in histoblast morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in morphogenesis of larval imaginal disc epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heteromeric SMAD protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    daughters against dpp
    Names
    CG5201-PA
    CG5201-PB
    CG5201-PC
    CG5201-PD
    Dad-PA
    Dad-PB
    Dad-PC
    Dad-PD
    anon-fast-evolving-1F5
    daughter against dpp
    daughters against Dpp

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17054007..17070408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057912.4 → NP_477260.1  daughters against dpp, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477260.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O15968, Q5U110
      Related
      FBpp0082834
      Conserved Domains (2) summary
      cd10489
      Location:197 → 329
      MH1_SMAD_6_7; N-terminal Mad Homology 1 (MH1) domain in SMAD6 and SMAD7
      cd10496
      Location:400 → 565
      MH2_I-SMAD; C-terminal Mad Homology 2 (MH2) domain in Inhibitory SMADs

    2. NM_001382177.1 → NP_001369021.1  daughters against dpp, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EEY2, O15968
      Conserved Domains (2) summary
      cd10489
      Location:197 → 329
      MH1_SMAD_6_7; N-terminal Mad Homology 1 (MH1) domain in SMAD6 and SMAD7
      cd10496
      Location:400 → 565
      MH2_I-SMAD; C-terminal Mad Homology 2 (MH2) domain in Inhibitory SMADs

    3. NM_001014629.2 → NP_001014629.1  daughters against dpp, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O15968, Q5U110
      Conserved Domains (2) summary
      cd10489
      Location:197 → 329
      MH1_SMAD_6_7; N-terminal Mad Homology 1 (MH1) domain in SMAD6 and SMAD7
      cd10496
      Location:400 → 565
      MH2_I-SMAD; C-terminal Mad Homology 2 (MH2) domain in Inhibitory SMADs

    4. NM_169740.2 → NP_732196.1  daughters against dpp, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O15968, Q5U110
      Related
      FBpp0082835
      Conserved Domains (2) summary
      cd10489
      Location:197 → 329
      MH1_SMAD_6_7; N-terminal Mad Homology 1 (MH1) domain in SMAD6 and SMAD7
      cd10496
      Location:400 → 565
      MH2_I-SMAD; C-terminal Mad Homology 2 (MH2) domain in Inhibitory SMADs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EEY2 A0A6H2EEY2
    O15968 O15968
    Q5U110 Q5U110
    Q8SZT4 Q8SZT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools