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    Lpt Lost PHDs of trr [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lptprovided by FlyBase
    Official Full Name
    Lost PHDs of trrprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263667
    Locus tag
    Dmel_CG5591
    See related
    AllianceGenome:FB:FBgn0263667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cara Mitad; cg5591; CG5591; cmi; Cmi; Dmel\CG5591; lpt; LPT
    Summary
    Enables several functions, including histone H3K4 methyltransferase activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Involved in imaginal disc-derived wing vein morphogenesis; positive regulation of ecdysone receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on ecdysis, chitin-based cuticle. Located in chromatin and polytene chromosome. Part of MLL3/4 complex. Is active in nucleus. Is expressed in several structures, including embryonic/larval midgut; ganglia; imaginal disc; spermatozoon; and wing cell. Used to study congenital heart disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Lpt in Genome Data Viewer
    Location:
    60A9-60A9; 2-105 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23898561..23903661)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19786084..19791184)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene Upf3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45926 Neighboring gene Nucleosome assembly protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New twists of a TAIL: novel insights into the histone binding properties of a highly conserved PHD finger cluster within the MLR family of H3K4 mono-methyltransferases. Zraly CB, et al. Nucleic Acids Res, 2023 Oct 13. PMID 37638761, Free PMC Article
    2. Enhancer malfunction in cancer. Herz HM, et al. Mol Cell, 2014 Mar 20. PMID 24656127, Free PMC Article
    3. The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate. Ford DJ, et al. Dev Biol, 2020 Dec 1. PMID 32946789
    4. The role of SETD1A and SETD1B in development and disease. Kranz A, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Aug. PMID 32389824
    5. Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability. Rickels R, et al. Nat Genet, 2017 Nov. PMID 28967912, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development.
      Title: Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K4 dimethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 monomethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ecdysone receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lost PHDs of trr
    Names
    CG5591-PA
    CG5591-PB
    Lpt-PA
    Lpt-PB
    cara mitad
    lost PHD finger of Trr
    lost PHDs of Trr
    NP_001286792.1
    NP_611847.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23898561..23903661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138003.3 → NP_611847.2  lost PHDs of trr, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611847.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1H0
      Related
      FBpp0072043
      Conserved Domains (9) summary
      smart00398
      Location:1173 → 1231
      HMG; high mobility group
      COG5648
      Location:1101 → 1237
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd15509
      Location:205 → 250
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15510
      Location:252 → 298
      PHD2_KMT2C_like; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15512
      Location:530 → 578
      PHD4_KMT2C_like; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD domain 3 found in KMT2D
      cd15513
      Location:580 → 625
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:657 → 707
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15665
      Location:109 → 191
      ePHD1_KMT2C_like; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cl22851
      Location:337 → 392
      PHD_SF; PHD finger superfamily

    2. NM_001299863.1 → NP_001286792.1  lost PHDs of trr, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGG6
      Conserved Domains (8) summary
      smart00398
      Location:1169 → 1227
      HMG; high mobility group
      COG5648
      Location:1097 → 1233
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd15509
      Location:205 → 250
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15510
      Location:252 → 298
      PHD2_KMT2C_like; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15512
      Location:530 → 578
      PHD4_KMT2C_like; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD domain 3 found in KMT2D
      cd15513
      Location:580 → 625
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:657 → 707
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cl22851
      Location:109 → 191
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGG6 A0A0B4LGG6
    Q961F0 Q961F0
    Q9W1H0 Q9W1H0

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