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    Hydr1 alpha/beta hydrolase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hydr1provided by FlyBase
    Official Full Name
    alpha/beta hydrolase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033382
    Locus tag
    Dmel_CG8058
    See related
    AllianceGenome:FB:FBgn0033382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8058; Dm.HYDR1; Dmel\CG8058
    Summary
    Predicted to enable acetylesterase activity and monoacylglycerol lipase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Is expressed in adult head. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hydr1 in Genome Data Viewer
    Location:
    45A11-45A11; 2-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9132480..9135453)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5019985..5022958)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein Neighboring gene alicorn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrub

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alpha/beta hydrolase2, a predicated gene adjacent to mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity. Wisotzkey RG, et al. J Mol Evol, 2003 Mar. PMID 12612838
    2. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
    3. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Asha H, et al. Genetics, 2003 Jan. PMID 12586708, Free PMC Article
    4. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    5. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables monoacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in medium-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    alpha/beta hydrolase 1
    Names
    CG8058-PA
    CG8058-PB
    CG8058-PC
    CG8058-PD
    CG8058-PE
    Hydr1-PA
    Hydr1-PB
    Hydr1-PC
    Hydr1-PD
    Hydr1-PE
    NP_001188892.1
    NP_001286229.1
    NP_001286230.1
    NP_610459.2
    NP_724757.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9132480..9135453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299300.1 → NP_001286229.1  alpha/beta hydrolase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN3, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:119 → 366
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:53 → 368
      Abhydrolase; alpha/beta hydrolases

    2. NM_001201963.2 → NP_001188892.1  alpha/beta hydrolase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q7, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:206 → 453
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:140 → 455
      Abhydrolase; alpha/beta hydrolases

    3. NM_165653.3 → NP_724757.2  alpha/beta hydrolase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724757.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN3, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:119 → 366
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:53 → 368
      Abhydrolase; alpha/beta hydrolases

    4. NM_136615.4 → NP_610459.2  alpha/beta hydrolase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610459.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q7, Q95S61
      Related
      FBpp0087661
      Conserved Domains (2) summary
      pfam00561
      Location:206 → 453
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:140 → 455
      Abhydrolase; alpha/beta hydrolases

    5. NM_001299301.1 → NP_001286230.1  alpha/beta hydrolase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN3, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:119 → 366
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:53 → 368
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7Q7 A1Z7Q7
    E2QCN3 E2QCN3
    Q95S61 Q95S61

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