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    spict spichthyin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spictprovided by FlyBase
    Official Full Name
    spichthyinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032451
    Locus tag
    Dmel_CG12292
    See related
    AllianceGenome:FB:FBgn0032451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12292; Dmel\CG12292; spg6; Spict
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Involved in negative regulation of BMP signaling pathway; negative regulation of synaptic assembly at neuromuscular junction; and positive regulation of axon extension involved in regeneration. Predicted to be active in membrane. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval dorsal vessel; gut section; larval central brain; and larval central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 6 and hereditary spastic paraplegia 6. Orthologous to several human genes including NIPAL1 (NIPA like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spict in Genome Data Viewer
    Location:
    33F3-33F3; 2-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12704725..12706683)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12704725..12706683)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon extension involved in regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spichthyin
    Names
    CG12292-PA
    CG12292-PB
    spict-PA
    spict-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12704725..12706683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135742.4 → NP_609586.1  spichthyin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK62
      Related
      FBpp0079978
      Conserved Domains (1) summary
      pfam05653
      Location:43 → 338
      Mg_trans_NIPA; Magnesium transporter NIPA

    2. NM_001273492.1 → NP_001260421.1  spichthyin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD12
      Conserved Domains (1) summary
      pfam05653
      Location:43 → 338
      Mg_trans_NIPA; Magnesium transporter NIPA
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD12 M9PD12
    Q9VK62 Q9VK62

    Gene LinkOut

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