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    Paics PAICS bifunctional enzyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paicsprovided by FlyBase
    Official Full Name
    PAICS bifunctional enzymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020513
    Locus tag
    Dmel_CG3989
    See related
    AllianceGenome:FB:FBgn0020513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ade5; Ade5; AIRc-SAICARs; CG3989; Dmel\CG3989
    Summary
    Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; female germline cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Paics in Genome Data Viewer
    Location:
    11B16-11B16; 1-39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12757036..12760617, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12651069..12654650, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene VSR interacting RNA Neighboring gene long non-coding RNA:CR44619 Neighboring gene pirate Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway. O'Donnell AF, et al. Genetics, 2000 Mar. PMID 10757766, Free PMC Article
    2. Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks. Cannavò E, et al. Curr Biol, 2016 Jan 11. PMID 26687625, Free PMC Article
    3. Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation. Sun Y, et al. Genome Res, 2015 Nov. PMID 26335633, Free PMC Article
    4. Neurodegeneration of Drosophila drop-dead mutants is associated with hypoxia in the brain. Kim JY, et al. Genes Brain Behav, 2012 Mar. PMID 22010830
    5. piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline. Chen P, et al. Genes Dev, 2021 Jun. PMID 33985970, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoribosylaminoimidazole carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    PAICS bifunctional enzyme
    Names
    AIR-carboxylase-SAICAR synthetase
    CG3989-PA
    CG3989-PB
    Paics-PA
    Paics-PB
    ade5
    NP_001259493.1
    NP_572826.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12757036..12760617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272564.1 → NP_001259493.1  PAICS bifunctional enzyme, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAN1
      Conserved Domains (2) summary
      cd01416
      Location:11 → 259
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:270 → 423
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    2. NM_132598.4 → NP_572826.1  PAICS bifunctional enzyme, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572826.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9I7S8, Q9TVK1
      Related
      FBpp0073538
      Conserved Domains (2) summary
      cd01416
      Location:12 → 260
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:271 → 424
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F0JAN1 F0JAN1
    Q9I7S8.2 Q9I7S8

    Gene LinkOut

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