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    Act57B Actin 57B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Act57Bprovided by FlyBase
    Official Full Name
    Actin 57Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000044
    Locus tag
    Dmel_CG10067
    See related
    AllianceGenome:FB:FBgn0000044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    act 57A; ACT3; Act57; act57A; Act57A; act57b; act57B; Act57b; actin; Actin; actin-57B; Actin-57B; anon-EST:CL2c12; ArpE; BEST:RE38067; C; CG10067; CG30294; chr2R:16452771..16452966; Dmel\CG10067; M; T10
    Summary
    Involved in ovarian fusome organization and regulation of synapse organization. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; border follicle cell; dorsal vessel; and larval muscle cell. Used to study hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 11. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1 and thrombocytopenia. Orthologous to human ACTB (actin beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Act57B in Genome Data Viewer
    Location:
    57B5-57B5; 2-92 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20944021..20946431)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16831526..16833936)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 15 Neighboring gene Retinal Homeobox Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene homeobrain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity. Schmidt W, et al. J Biol Chem, 2020 Nov 13. PMID 32873710, Free PMC Article
    2. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Viswanathan MC, et al. Cell Rep, 2017 Sep 12. PMID 28903042, Free PMC Article
    3. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages. Kelly KK, et al. Mech Dev, 2002 Jan. PMID 11744367
    4. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Bahadorani S, et al. Dis Model Mech, 2010 Jan-Feb. PMID 20038716
    5. Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance. Viswanathan MC, et al. Front Physiol, 2015. PMID 25972811, Free PMC Article

    See all (211) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages.
      Title: Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ovarian fusome organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    actin 57B
    Names
    Act57B-PA
    Actin-57B
    CG10067-PA
    F-actin
    actin
    actin57B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20944021..20946431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079076.4 → NP_523800.1  actin 57B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53501, Q9W2Q0
      UniProtKB/TrEMBL
      C6TP14, C8VV69
      Related
      FBpp0071448
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53501.1 P53501

    Gene LinkOut

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