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    kuk kugelkern [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kukprovided by FlyBase
    Official Full Name
    kugelkernprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038476
    Locus tag
    Dmel_CG5175
    See related
    AllianceGenome:FB:FBgn0038476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5175; char; Dmel\CG5175; Kuk; kuk/char
    Summary
    Involved in cellularization; morphogenesis of embryonic epithelium; and nucleus organization. Located in nuclear inner membrane. Is expressed in several structures, including CNS glial cell; head epidermis primordium; mesoderm; unpaired neurons; and ventral nerve cord. Used to study progeroid syndrome. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kuk in Genome Data Viewer
    Location:
    89E12-89E12; 3-59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17080244..17084781)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12905966..12910503)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene Keap1 Neighboring gene Germinal centre kinase III Neighboring gene chromosome alignment defect 1 Neighboring gene cheerio

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina.
      Title: Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane.
    2. Induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies.
      Title: The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.
    3. Kugelkern encodes a coiled-coil protein with nuclear localization signal and CxxM motif and is required for nuclear elongation.
      Title: Developmental control of nuclear size and shape by Kugelkern and Kurzkern.
    4. Char is lipid anchored at the nuclear envelope by a farnesylation group, and localises at the inner nuclear membrane. Char forms a scaffold that regulates nuclear architecture to constrain nuclei in tight columnar epithelial cells.
      Title: Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kugelkern
    Names
    CG5175-PA
    CG5175-PB
    CG5175-PC
    Kugelkern/Charleston
    charleston
    kugelkem
    kuk-PA
    kuk-PB
    kuk-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17080244..17084781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142338.3 → NP_650595.1  kugelkern, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DML4, Q8SX89, Q9VEN4
      Related
      FBpp0082838
      Conserved Domains (1) summary
      pfam10243
      Location:95 → 290
      MIP-T3; Microtubule-binding protein MIP-T3

    2. NM_001260219.1 → NP_001247148.1  kugelkern, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DML4, Q8SX89, Q9VEN4
      Conserved Domains (1) summary
      pfam10243
      Location:95 → 290
      MIP-T3; Microtubule-binding protein MIP-T3

    3. NM_169745.3 → NP_732204.1  kugelkern, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DML4, Q8SX89, Q9VEN4
      Related
      FBpp0082839
      Conserved Domains (1) summary
      pfam10243
      Location:95 → 290
      MIP-T3; Microtubule-binding protein MIP-T3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX89 Q8SX89

    Gene LinkOut

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