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    Cftr CF transmembrane conductance regulator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cftrprovided by FlyBase
    Official Full Name
    CF transmembrane conductance regulatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039207
    Locus tag
    Dmel_CG5789
    See related
    AllianceGenome:FB:FBgn0039207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CFTR; CG5789; DmCG5789; Dmel\CFTR; Dmel\CG5789; Dme_CG5789
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Used to study cystic fibrosis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cftr in Genome Data Viewer
    Location:
    96A6-96A7; 3-85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24536204..24543914, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20361926..20369636, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Juvenile hormone binding protein 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene anastral spindle 1 Neighboring gene Extended synaptotagmin-like protein 2 Neighboring gene transfer RNA:Aspartic acid-GTC 1-11 Neighboring gene small nuclear RNA U6 at 96A a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections. Touré H, et al. Infect Immun, 2023 Nov 16. PMID 37847031, Free PMC Article
    2. Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. Kim K, et al. Proc Natl Acad Sci U S A, 2020 May 12. PMID 32345720, Free PMC Article
    3. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810
    4. Bioelectric regulation of intestinal stem cells. Petsakou A, et al. Trends Cell Biol, 2023 Jul. PMID 36396487, Free PMC Article
    5. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. Mayer F, et al. J Neurosci, 2009 Mar 18. PMID 19295159, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CF transmembrane conductance regulator
    Names
    CG5789-PA
    CG5789-PB
    Cftr-PA
    Cftr-PB
    NP_001247286.1
    NP_651269.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24536204..24543914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143012.3 → NP_651269.1  CF transmembrane conductance regulator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHL5, Q9VC63
      Related
      FBpp0088845
      Conserved Domains (4) summary
      cd03244
      Location:1135 → 1350
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:495 → 699
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:9 → 1367
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:863 → 1088
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001260357.1 → NP_001247286.1  CF transmembrane conductance regulator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHL5, Q9VC63
      Conserved Domains (4) summary
      cd03244
      Location:1135 → 1350
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:495 → 699
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:9 → 1367
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:863 → 1088
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC63 Q9VC63

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