stck steamer duck [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stckprovided by FlyBase
Official Full Name: steamer duckprovided by FlyBase
Primary source: FLYBASE:FBgn0020249
Locus tag: Dmel_CG7954
See related: AllianceGenome:FB:FBgn0020249
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7954; D-PINCH; Dmel\CG7954; dpin; dPINCH; pin85A; pinch; Pinch; PINCH; Stck; stk
Summary: Involved in several processes, including apposition of dorsal and ventral imaginal disc-derived wing surfaces; embryonic development via the syncytial blastoderm; and negative regulation of JNK cascade. Located in cell leading edge and focal adhesion. Is expressed in several structures, including adult head; mesoderm; muscle attachment site; visceral mesoderm; and visceral muscle primordium. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to human LIMS1 (LIM zinc finger domain containing 1) and LIMS2 (LIM zinc finger domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 84F15-84F15; 3-48 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8356978..8359964)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4182700..4185686)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH, and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
Title: Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis.
By testing a panel of IAC proteins, we show specificity for PINCH expression in the rescue of hypercontraction mutants
Title: Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants.
PINCH and ILK have an independent capacity to localize at muscle attachment sites in vivo.
Title: A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted.
Both PINCH and RSU-1 antagonize JNK signaling during Drosophila embryonic dorsal closure, suggesting both PINCH and RSU-1 contribute to the integration of JNK and integrin functions during Drosophila development
Title: The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: steamer duck

Names: CG7954-PA; CG7954-PB; CG7954-PC; CG7954-PD; PINCH; d-pinch; stck-PA; stck-PB; stck-PC; stck-PD; steamerduck

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8356978..8359964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260058.2 → NP_001246987.1 steamer duck, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246987.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XYA7

Conserved Domains (5) summary

cd09331
Location:8 → 66

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:69 → 120

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:133 → 193

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:199 → 252

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:260 → 313

LIM5_PINCH; The fifth LIM domain of protein PINCH
NM_079554.4 → NP_524278.1 steamer duck, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524278.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XYA7

Related

FBpp0081334

Conserved Domains (5) summary

cd09331
Location:8 → 66

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:69 → 120

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:133 → 193

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:199 → 252

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:260 → 313

LIM5_PINCH; The fifth LIM domain of protein PINCH
NM_169220.3 → NP_731241.1 steamer duck, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731241.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8INR0

Related

FBpp0081335

Conserved Domains (5) summary

cd09331
Location:18 → 76

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:79 → 130

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:143 → 203

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:209 → 262

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:270 → 323

LIM5_PINCH; The fifth LIM domain of protein PINCH
NM_169221.3 → NP_731242.1 steamer duck, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731242.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8INQ9

Related

FBpp0081336

Conserved Domains (5) summary

cd09331
Location:21 → 79

LIM1_PINCH; The first LIM domain of protein PINCH

cd09332
Location:82 → 133

LIM2_PINCH; The second LIM domain of protein PINCH

cd09333
Location:146 → 206

LIM3_PINCH; The third LIM domain of protein PINCH

cd09334
Location:212 → 265

LIM4_PINCH; The fourth LIM domain of protein PINCH

cd09335
Location:273 → 326

LIM5_PINCH; The fifth LIM domain of protein PINCH