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    Pex1 Peroxin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pex1provided by FlyBase
    Official Full Name
    Peroxin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0013563
    Locus tag
    Dmel_CG6760
    See related
    AllianceGenome:FB:FBgn0013563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0848/07; anon-WO0172774.100; anon-WO0172774.101; anon-WO0172774.102; anon-WO0172774.96; anon-WO0172774.98; anon-WO0172774.99; CG6760; DmCAB51031.1; DmelPex1; Dmel\CG6760; l(3)02402; l(3)084807; l(3)70Da; l(3)S084807; l(3)s4868; pex1; PEX1
    Summary
    Predicted to enable ATP hydrolysis activity; protein transporter activity; and ubiquitin-modified protein reader activity. Involved in nervous system development and peroxisome organization. Located in peroxisome. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Used to study Zellweger syndrome and peroxisome biogenesis disorder 14B. Human ortholog(s) of this gene implicated in Heimler syndrome 1; peroxisome biogenesis disorder 1A; and peroxisome biogenesis disorder 1B. Orthologous to human PEX1 (peroxisomal biogenesis factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pex1 in Genome Data Viewer
    Location:
    70D1-70D2; 3-42 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14071892..14076123)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14064992..14069223)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46067 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Formin-like Neighboring gene breathless Neighboring gene uncharacterized protein Neighboring gene Fat body protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Midlife gene expressions identify modulators of aging through dietary interventions. Zhou B, et al. Proc Natl Acad Sci U S A, 2012 May 8. PMID 22509016, Free PMC Article
    2. Versatility of peroxisomes: An evolving concept. Deb R, et al. Tissue Cell, 2017 Apr. PMID 28347500
    3. Genetic and molecular analysis in the 70CD region of the third chromosome of Drosophila melanogaster. Burmester T, et al. Gene, 2000 Apr 4. PMID 10767537
    4. The role of Peroxin 7 during Drosophila embryonic development. Pridie C, et al. Genome, 2021 Feb. PMID 32191843
    5. The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation. Russell SR, et al. Development, 1996 Nov. PMID 8951082

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-modified protein reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix, receptor recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein unfolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein unfolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxin 1
    Names
    CG6760-PA
    Pex1-PA
    lethal (3) 70Da

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14071892..14076123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143759.3 → NP_652016.1  peroxin 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652016.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC7, Q9Y090
      Related
      FBpp0075519
      Conserved Domains (4) summary
      COG0464
      Location:479 → 974
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:757 → 887
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09262
      Location:93 → 168
      PEX-1N; Peroxisome biogenesis factor 1, N-terminal
      cl21455
      Location:480 → 604
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUC7 Q9VUC7
    Q9Y090 Q9Y090

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