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    Ing5 Inhibitor of growth family member 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ing5provided by FlyBase
    Official Full Name
    Inhibitor of growth family member 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0032516
    Locus tag
    Dmel_CG9293
    See related
    AllianceGenome:FB:FBgn0032516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9293; Dmel\CG9293
    Summary
    Enables acetyltransferase activator activity. Predicted to be involved in regulation of DNA-templated transcription. Part of MOZ/MORF histone acetyltransferase complex. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to several human genes including ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ing5 in Genome Data Viewer
    Location:
    34B9-34B9; 2-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13385848..13387312, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13385848..13387312, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) beta' Neighboring gene loquacious Neighboring gene antisense RNA:CR44599 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L24 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons. Estes PS, et al. Mol Cell Neurosci, 2008 Oct. PMID 18655836
    2. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
    3. Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. Kim JC, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933960, Free PMC Article
    4. Fragile X protein functions with lgl and the par complex in flies and mice. Zarnescu DC, et al. Dev Cell, 2005 Jan. PMID 15621528
    5. Identification of novel Drosophila centromere-associated proteins. Barth TK, et al. Proteomics, 2014 Oct. PMID 24841622

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
      Title: Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth family member 5
    Names
    CG9293-PA
    CG9293-PB
    Ing5-PA
    Ing5-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13385848..13387312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165042.3 → NP_723814.1  inhibitor of growth family member 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IP71
      Related
      FBpp0080104
      Conserved Domains (3) summary
      COG5034
      Location:1 → 264
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15586
      Location:220 → 264
      PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
      pfam12998
      Location:6 → 108
      ING; Inhibitor of growth proteins N-terminal histone-binding

    2. NM_135803.4 → NP_609647.1  inhibitor of growth family member 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IP71, Q95RB4, Q9VJY8
      Related
      FBpp0080103
      Conserved Domains (3) summary
      COG5034
      Location:1 → 278
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15586
      Location:234 → 278
      PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
      pfam12998
      Location:6 → 108
      ING; Inhibitor of growth proteins N-terminal histone-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJY8.2 Q9VJY8

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