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    Septin4 Septin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Septin4provided by FlyBase
    Official Full Name
    Septin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0259923
    Locus tag
    Dmel_CG9699
    See related
    AllianceGenome:FB:FBgn0259923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    04-Sep; CG9699; Dmel\CG9699; dSEPT4; sep4; Sep4
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of exocytosis. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle. Is expressed in several structures, including adult head; brain; central brain primordium; dopaminergic neurons; and embryonic dorsal vessel. Orthologous to several human genes including SEPTIN4 (septin 4) and SEPTIN5 (septin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Septin4 in Genome Data Viewer
    Location:
    15A1-15A1; 1-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16684216..16695173, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16578249..16589206, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene singles bar Neighboring gene Abnormal X segregation Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spheroide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Septin 4, the Drosophila homologue of human CDCrel-1, is toxic for dopaminergic neurons. Muñoz-Soriano V, et al. Eur J Neurosci, 2007 Dec. PMID 18028112
    2. Conservation and divergence of the G-interfaces of Drosophila melanogaster septins. de Freitas Fernandes A, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36576069
    3. Septins From Protists to People. Shuman B, et al. Front Cell Dev Biol, 2021. PMID 35111763, Free PMC Article
    4. Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5. O'Neill RS, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172205, Free PMC Article
    5. Comparative analysis of the brain transcriptome in a hyper-aggressive fruit fly, Drosophila prolongata. Kudo A, et al. Insect Biochem Mol Biol, 2017 Mar. PMID 28115271

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sep4 could be a Park substrate in Drosophila.
      Title: Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin 4
    Names
    CG9699-PA
    CG9699-PB
    CG9699-PC
    CG9699-PD
    CG9699-PE
    CG9699-PF
    CG9699-PG
    Sep4
    Septin4-PA
    Septin4-PB
    Septin4-PC
    Septin4-PD
    Septin4-PE
    Septin4-PF
    Septin4-PG
    septin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16684216..16695173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167530.2 → NP_728003.1  septin 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728003.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR7, Q960I4
      Related
      FBpp0074139
      Conserved Domains (2) summary
      cd01850
      Location:82 → 357
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:65 → 420
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    2. NM_167531.2 → NP_728004.1  septin 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728004.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR7, Q960I4
      Related
      FBpp0074141
      Conserved Domains (2) summary
      cd01850
      Location:82 → 357
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:65 → 420
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    3. NM_167534.2 → NP_728007.1  septin 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR7, Q960I4
      Related
      FBpp0074140
      Conserved Domains (2) summary
      cd01850
      Location:82 → 357
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:65 → 420
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    4. NM_132919.3 → NP_573147.2  septin 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573147.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR7, Q960I4
      Related
      FBpp0074144
      Conserved Domains (2) summary
      cd01850
      Location:82 → 357
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:65 → 420
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    5. NM_167533.2 → NP_728006.1  septin 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR7, Q960I4
      Related
      FBpp0074143
      Conserved Domains (2) summary
      cd01850
      Location:82 → 357
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:65 → 420
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    6. NM_167532.2 → NP_728005.1  septin 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR7, Q960I4
      Related
      FBpp0074142
      Conserved Domains (2) summary
      cd01850
      Location:82 → 357
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:65 → 420
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    7. NM_206766.2 → NP_996489.1  septin 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV45, Q7KUX3
      Conserved Domains (1) summary
      cd01850
      Location:30 → 305
      CDC_Septin; CDC/Septin GTPase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHR7 Q0KHR7
    Q7KUX3 Q7KUX3
    Q95RN2 Q95RN2
    Q960I4 Q960I4

    Gene LinkOut

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