Srr Serine racemase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Srrprovided by FlyBase
Official Full Name: Serine racemaseprovided by FlyBase
Primary source: FLYBASE:FBgn0037684
Locus tag: Dmel_CG8129
See related: AllianceGenome:FB:FBgn0037684
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8129; CT24308; Dmel\CG8129; sr; SR; stdh
Summary: Predicted to enable L-serine ammonia-lyase activity; serine racemase activity; and threonine deaminase activity. Predicted to be involved in L-serine catabolic process; isoleucine biosynthetic process; and threonine catabolic process. Is expressed in yolk nucleus. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85D12-85D13; 3-48 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9365398..9367763)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5191120..5193485)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results suggest that D-serine made by intestinal serine racemase promotes sleep through NMDAR1 in Drosophila.
Title: D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-serine ammonia-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine racemase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-serine catabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine racemase

Names: CG8129-PA; CG8129-PB; Srr-PA; Srr-PB; serine/threonine dehydratase

NP_649886.1

EC 4.3.1.17

EC 4.3.1.19

EC 5.1.1.18

NP_731340.1

EC 4.3.1.17

EC 4.3.1.19

EC 5.1.1.18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9365398..9367763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141629.3 → NP_649886.1 serine racemase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649886.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VHE9, Q9VHF0

Related

FBpp0081504

Conserved Domains (3) summary

cd01562
Location:61 → 364

Thr-dehyd; Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly ...

cd04886
Location:385 → 449

ACT_ThrD-II-like; C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains

PRK08198
Location:58 → 449

PRK08198; threonine dehydratase; Provisional
NM_169273.2 → NP_731340.1 serine racemase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731340.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KST5

Related

FBpp0081505

Conserved Domains (2) summary

cd04886
Location:232 → 296

ACT_ThrD-II-like; C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains

cl00342
Location:1 → 211

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...