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    Mcm6 Minichromosome maintenance 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcm6provided by FlyBase
    Official Full Name
    Minichromosome maintenance 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0025815
    Locus tag
    Dmel_CG4039
    See related
    AllianceGenome:FB:FBgn0025815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6
    Summary
    Contributes to 3'-5' DNA helicase activity. Involved in DNA replication and eggshell chorion gene amplification. Located in nucleus. Part of CMG complex and MCM complex. Is expressed in presumptive embryonic/larval central nervous system and unfertilized egg. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mcm6 in Genome Data Viewer
    Location:
    6C4-6C5; 1-18 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6674387..6677176)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6568420..6571209)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Copper transporter 1A Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) ASHI subunit Neighboring gene Fumarase 1 Neighboring gene Fumarase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutants suppressing in trans chorion gene amplification in Drosophila. Orr W, et al. Proc Natl Acad Sci U S A, 1984 Jun. PMID 6427774, Free PMC Article
    2. Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4. McDaniel SL, et al. Genetics, 2020 Feb. PMID 31818869, Free PMC Article
    3. Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Tain LS, et al. Elife, 2021 Apr 21. PMID 33879316, Free PMC Article
    4. Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mapping. Gallone G, et al. BMC Bioinformatics, 2011 Jul 18. PMID 21767381, Free PMC Article
    5. A novel transcriptional cascade is involved in Fzr-mediated endoreplication. Qian W, et al. Nucleic Acids Res, 2020 May 7. PMID 32182338, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eggshell chorion gene amplification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    minichromosome maintenance 6
    Names
    CG4039-PA
    Mcm6-PA
    female sterile(1)K1214

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6674387..6677176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078510.3 → NP_511065.1  minichromosome maintenance 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511065.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96047, Q960E3, Q9V461
      UniProtKB/TrEMBL
      C6SUY3
      Related
      FBpp0070913
      Conserved Domains (3) summary
      smart00350
      Location:113 → 649
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:22 → 109
      MCM_N; MCM N-terminal domain
      pfam18263
      Location:702 → 816
      MCM6_C; MCM6 C-terminal winged-helix domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V461.1 Q9V461

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
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