Porin2 Porin2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Porin2provided by FlyBase
Official Full Name: Porin2provided by FlyBase
Primary source: FLYBASE:FBgn0069354
Locus tag: Dmel_CG17137
See related: AllianceGenome:FB:FBgn0069354
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:LP07660; CG17137; Dmel\CG17137; DmPorin2; FBgn0069354; LP07660.3prime; porin 2; Porin 2
Summary: Enables monoatomic cation channel activity and porin activity. Involved in mitochondrial transmembrane transport and monoatomic ion transport. Located in mitochondrion. Is expressed in adult head; ovarian sheath; ovary; spermatozoon; and testis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human VDAC1 (voltage dependent anion channel 1) and VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10845788..10847044, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10845788..10847044, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

DmPorin2 is expressed in all the fly tissues and in all the developmental stages tested; it forms voltage-independent cation-selective pores
Title: Functional characterization of a second porin isoform in Drosophila melanogaster. DmPorin2 forms voltage-independent cation-selective pores.
Porin 2 is truly expressed and that it is required for functional germinal tissues
Title: Expression and localization in spermatozoa of the mitochondrial porin isoform 2 in Drosophila melanogaster.

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Function	Evidence Code	Pubs
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables porin activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

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