tra transformer [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: traprovided by FlyBase
Official Full Name: transformerprovided by FlyBase
Primary source: FLYBASE:FBgn0003741
Locus tag: Dmel_CG16724
See related: AllianceGenome:FB:FBgn0003741
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG16724; Dmel\CG16724; Dmtra; Tra; TRA
Summary: Enables pre-mRNA binding activity. Involved in several processes, including epithelium regeneration; female sex determination; and mRNA splicing, via spliceosome. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 73A10-73A10; 3-44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16590059..16591050, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16583159..16584150, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway.
Title: Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway.
Transcriptional control of the sex determination hierarchy by Chinmo is critical for sex maintenance in sexually dimorphic tissues and is vital in the preservation of fertility. Chinmo prevents transformer alternative splicing to maintain male sex identity.
Title: Chinmo prevents transformer alternative splicing to maintain male sex identity.
Drosophila female-specific Ilp7 motoneurons are generated by Fruitless-dependent cell death in males and by a double-assurance survival role for Transformer in females
Title: Drosophila female-specific Ilp7 motoneurons are generated by Fruitless-dependent cell death in males and by a double-assurance survival role for Transformer in females.
tra expression play crucial role in determining sex-specific size in Drosophila larvae and adult tissue.
Title: Sexual Dimorphism of Body Size Is Controlled by Dosage of the X-Chromosomal Gene Myc and by the Sex-Determining Gene tra in Drosophila.
body size is regulated by tra in a sex-specific fashion.
Title: The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size.
When tsh(GAL4) drove expression of transformer (tra), males were unable to produce prolonged wing extensions.
Title: Genetic feminization of the thoracic nervous system disrupts courtship song in male Drosophila melanogaster.
Effect of tra of Tephritidae on the somatic sexual development of Drosophila are reported.
Title: Effect of the gene transformer of Anastrepha on the somatic sexual development of Drosophila.
the reciprocal regulatory effect by studying genetically sensitized females: TRA-F from either maternal or zygotic tra expression stimulates sex-lethal -positive autoregulation.
Title: Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer.
tra sequence variation among members of the Drosophila melanogaster species complex, D. melanogaster, D. simulans, D. mauritiana, and D. sechellia
Title: Rapid evolution of the sex-determining gene, transformer: structural diversity and rate heterogeneity among sibling species of Drosophila.
In gynanders (XX//XO mosaics) feminized by this Tra(F) transgene, functionally Sxl- haplo-X (chromosomally male) somatic cells collaborated successfully with diplo-X (chromosomally female) germ cells to make functional eggs.
Title: Drosophila melanogaster male somatic cells feminized solely by TraF can collaborate with female germ cells to make functional eggs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables pre-mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelium regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female sex determination	IDA Inferred from Direct Assay more info	PubMed
involved_in female sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female sex differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in female sex differentiation	IEA Inferred from Electronic Annotation more info
involved_in female sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed