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    Rsf1 Repressor splicing factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rsf1provided by FlyBase
    Official Full Name
    Repressor splicing factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0011305
    Locus tag
    Dmel_CG5655
    See related
    AllianceGenome:FB:FBgn0011305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5655; Dmel\CG5655; dRSF1; rox21; Rox21; ROX21; RSF1
    Summary
    Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA 3'-end processing; and regulation of transcriptional start site selection at RNA polymerase II promoter. Located in nucleus. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rsf1 in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10261795..10263554, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10261795..10263554, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ror Neighboring gene uncharacterized protein Neighboring gene Phosphatase and tensin homolog Neighboring gene REPTOR-binding partner Neighboring gene MOB kinase activator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recognition of exonic splicing enhancer sequences by the Drosophila splicing repressor RSF1. Labourier E, et al. Nucleic Acids Res, 1999 Jun 1. PMID 10325428, Free PMC Article
    2. Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy. Brand SF, et al. Gene, 1995 Mar 10. PMID 7890163
    3. Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development. Labourier E, et al. Genes Dev, 1999 Mar 15. PMID 10090730, Free PMC Article
    4. The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. Bennick RA, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31277943
    5. The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila. Zhang Z, et al. Sci Rep, 2018 Jan 30. PMID 29382842, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    repressor splicing factor 1
    Names
    CG5655-PA
    CG5655-PB
    Rsf1-PA
    Rsf1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10261795..10263554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273389.1 → NP_001260318.1  repressor splicing factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24424, Q24491, Q9VL15
      UniProtKB/TrEMBL
      Q8SYR3
      Conserved Domains (1) summary
      cd12373
      Location:11 → 82
      RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

    2. NM_057653.3 → NP_477001.2  repressor splicing factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477001.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24424, Q24491, Q9VL15
      UniProtKB/TrEMBL
      Q8SYR3
      Related
      FBpp0079668
      Conserved Domains (1) summary
      cd12373
      Location:11 → 82
      RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24491.1 Q24491
    Q8SYR3 Q8SYR3

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