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    Arp53D Actin-related protein 53D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arp53Dprovided by FlyBase
    Official Full Name
    Actin-related protein 53Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011743
    Locus tag
    Dmel_CG5409
    See related
    AllianceGenome:FB:FBgn0011743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Actr53D; arp5; arp53D; ARP53D; ArpG; Arp_G; CG5409; Dmel\CG5409
    Summary
    Involved in positive regulation of embryonic development. Located in actin cytoskeleton and fusome. Is expressed in testis. Human ortholog(s) of this gene implicated in male infertility; spermatogenic failure 53; and spermatogenic failure 86. Orthologous to several human genes including ACTL10 (actin like 10); ACTL7A (actin like 7A); and ACTL7B (actin like 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arp53D in Genome Data Viewer
    Location:
    53D8-53D8; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16774246..16775676)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12661751..12663181)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncoordinated-104 Neighboring gene uncharacterized protein Neighboring gene Superoxide dismutase 2 (Mn) Neighboring gene Vitamin-K epoxide reductase Neighboring gene resilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development. Schroeder CM, et al. Elife, 2021 Jul 20. PMID 34282725, Free PMC Article
    2. Deletions encompassing the manganese superoxide dismutase gene in the Drosophila melanogaster genome. Belton A, et al. Genome, 2006 Jul. PMID 16936783
    3. Genes encoding actin-related proteins of Drosophila melanogaster. Fyrberg C, et al. J Mol Biol, 1994 Aug 19. PMID 8064864
    4. Genes encoding vitamin-K epoxide reductase are present in Drosophila and trypanosomatid protists. Robertson HM. Genetics, 2004 Oct. PMID 15514077, Free PMC Article
    5. Actin' like actin? Mullins RD, et al. Trends Cell Biol, 1996 Jun. PMID 15157457

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development.
      Title: An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Actin-related protein 53D
    Names
    Arp53D-PB
    CG5409-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16774246..16775676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057689.4 → NP_477037.2  Actin-related protein 53D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477037.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAT3
      Conserved Domains (2) summary
      smart00268
      Location:46 → 411
      ACTIN; Actin
      cl17037
      Location:47 → 411
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45891.2 P45891

    Gene LinkOut

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