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    Elp5 Elongator complex protein 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elp5provided by FlyBase
    Official Full Name
    Elongator complex protein 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0015359
    Locus tag
    Dmel_CG2034
    See related
    AllianceGenome:FB:FBgn0015359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-i1; CG2034; Dmel\CG2034
    Summary
    Predicted to contribute to tRNA binding activity. Involved in establishment of mitotic spindle asymmetry. Part of elongator holoenzyme complex. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Elp5 in Genome Data Viewer
    Location:
    62D4-62D4; 3-2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2257456..2258922)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2257456..2258922)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene peptide O-xylosyltransferase Neighboring gene uncharacterized protein Neighboring gene ecdysoneless Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
    2. A misexpression screen to identify regulators of Drosophila larval hemocyte development. Stofanko M, et al. Genetics, 2008 Sep. PMID 18757933, Free PMC Article
    3. Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED. Hadžić T, et al. Nucleic Acids Res, 2015 Feb 27. PMID 25634895, Free PMC Article
    4. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624
    5. Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Islam MS, et al. Hum Mol Genet, 2016 Dec 15. PMID 27794539, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle asymmetry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    elongator complex protein 5
    Names
    CG2034-PA
    CG2034-PB
    Elp5-PA
    Elp5-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2257456..2258922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274393.1 → NP_001261322.1  elongator complex protein 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24050

    2. NM_139447.2 → NP_647704.1  elongator complex protein 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24050
      Related
      FBpp0072756
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24050 Q24050

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